Evidence map›Paper›PMID 35229348›Full record

ArticleMicrobiology and immunology2022

Gene expression in lung epithelial cells following interaction with Pneumocystis carinii and its specific life forms yields insights into host gene responses to infection.

Theodore J Kottom, Eva M Carmona, Andrew H Limper

Open access · greenAbstract read
In one paragraph

Article in Microbiology and immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Extracellular vesicles fromMicrobiology spectrum · 2024
    Article
  3. Lung Epithelial Cell Line Immune Responses toJournal of fungi (Basel, Switzerland) · 2023
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Theodore J KottomThoracic Diseases Research Unit, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.ORCID http://orcid.org/0000-0003-0364-3311
Eva M CarmonaThoracic Diseases Research Unit, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Andrew H LimperThoracic Diseases Research Unit, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Mayo Clinic · US

Funding

Pneumocystis: Macrophage & Epithelial ActivationR01HL062150 · NHLBI · MAYO CLINIC ROCHESTER · PI ANDREW H LIMPER · 1998 to 2026
$9.2M
Mayo Foundation, the Walter and Leonore Annenberg Foundation, and NIHNHLBI NIH HHS R01 HL062150NIH HHS HL62150
6 · The paper itself

Abstract

Pneumocystis spp. interacts with epithelial cells in the alveolar spaces of the lung. It is thought that the binding of Pneumocystis to host cell epithelium is needed for life cycle completion and proliferation. The effect of this interaction on lung epithelial cells has previously shown that the trophic form of this organism greatly inhibits p34

Indexed as

PneumocystisPneumocystis cariniiPneumonia, PneumocystisEpithelial CellsGene ExpressionLungReproducibility of ResultsA549epitheliummicroarrayPneumocystis

Identifiers

PMID35229348
PMCPMC9090966
OpenAlexW4214698874

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.