Evidence map›Paper›PMID 35229272›Full record

ArticleNeurochemical research2022

CircAXL Knockdown Alleviates Aβ

Shengxi Meng, Bing Wang, Wentao Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  4. Article
  5. Review
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  7. Review
  8. Review
  9. Review
  10. Article
  11. Circular RNAs as Biomarkers in the Diagnosis of Human Diseases.Advances in experimental medicine and biology · 2025
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Shengxi MengDepartment of Traditional Chinese Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yi Shan Road, Xuhui District, Shanghai, 200233, China. mengsx163@163.com.
Bing WangDepartment of Traditional Chinese Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yi Shan Road, Xuhui District, Shanghai, 200233, China.
Wentao LiDepartment of Encephalopathy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai City, China.
Shanghai Jiao Tong University · CNShanghai Sixth People's Hospital · CNShanghai Traditional Chinese Medicine Hospital · CN

Funding

2019 Teacher Training and Development Project of Medical School of Shanghai Jiao Tong University No.JFXM201909Innovation Fund of Integrated Traditional Chinese and Western Medicine, School of Medicine, Shanghai Jiao Tong University No.18zxy002Project of Shanghai Science and Technology Commission No.19401932500Project of Shanghai Science and Technology Commission No.19401970600Shanghai will further accelerate the three-year action plan for the development of TCM (2018-2020) for major clinical research on TCM ZY (2018-2020)-CCCX-4010
6 · The paper itself

Abstract

The development of Alzheimer's disease (AD) is implicated with the dysregulation of numerous circular RNAs (circRNAs). However, the function of several circRNAs remains unclear. The aim of this study was to investigate the role of circular AXL receptor tyrosine kinase (circAXL) in AD. Cell models of AD were constructed by treating SK-N-SH cells with amyloid-β (Aβ

Indexed as

Alzheimer DiseaseMicroRNAsNeurotoxicity SyndromesAmyloid beta-PeptidesApoptosisCyclic Nucleotide Phosphodiesterases, Type 4HumansPeptide FragmentsRNA, CircularAmyloid beta-Peptidesamyloid beta-protein (1-42)Cyclic Nucleotide Phosphodiesterases, Type 4MicroRNAsPDE4A protein, humanPeptide FragmentsRNA, CircularAlzheimer’s diseaseAβ1-42circAXLmiR-1306-5pPDE4A

Identifiers

PMID35229272
PMCPMC9124172
OpenAlexW4214622474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.