Evidence map›Paper›PMID 35229237›Full record

ArticlePharmaceutical research2022

Calcium Enabled Remote Loading of a Weak Acid Into pH-sensitive Liposomes and Augmented Cytosolic Delivery to Cancer Cells via the Proton Sponge Effect.

Mimi M Yang, Sasi Bhushan Yarragudi, Stephen M F Jamieson, Mingtan Tang, William R Wilson, Zimei Wu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mimi M Yang *School of Pharmacy, The University of Auckland, Auckland, 1142, New Zealand.
Sasi Bhushan Yarragudi *School of Pharmacy, The University of Auckland, Auckland, 1142, New Zealand.
Stephen M F JamiesonAuckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.
Mingtan TangSchool of Pharmacy, The University of Auckland, Auckland, 1142, New Zealand.
William R WilsonAuckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.
Zimei WuSchool of Pharmacy, The University of Auckland, Auckland, 1142, New Zealand. z.wu@auckland.ac.nz.ORCID http://orcid.org/0000-0001-9777-0674
University of Auckland · NZ

Funding

Marsden Fund UOA1201The University of Auckland FRDF 3716807
6 · The paper itself

Abstract

While delivery of chemotherapeutics to cancer cells by nanomedicines can improve therapeutic outcomes, many fail due to the low drug loading (DL), poor cellular uptake and endosomal entrapment. This study investigated the potential to overcome these limitations using pH-sensitive liposomes (PSL) empowered by the use of calcium acetate. An acidic dinitrobenzamide mustard prodrug SN25860 was used as a model drug, with non pH-sensitive liposomes (NPSL) as a reference. Calcium acetate as a remote loading agent allowed to engineer PSL- and NPSL-SN25860 with DL of > 31.1% (w/w). The IC

Indexed as

LiposomesNeoplasmsAnimalsCalciumCell Line, TumorDrug Delivery SystemsEndosomesHydrogen-Ion ConcentrationMiceProtonsCalciumLiposomesProtonsCalcium acetateCo-localization analysisCytosolic deliveryEndosomal entrapmentpH-sensitive liposomesProton sponge effectRemote drug loading

Identifiers

PMID35229237
PMCPMC9197910
OpenAlexW4214703909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.