ArticleJournal of neurology2022
Understanding the interaction between clinical, emotional and psychophysical outcomes underlying tension-type headache: a network analysis approach.
Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07240532 (Efficacy of a Multimodal Physiotherapy Program and Mobile-App Guided Meditation in Adults With Frequent or Chronic Tension-Type Headache), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of a Multimodal Physiotherapy Program and Mobile-App Guided Meditation in Adults With Frequent or Chronic Tension-Type Headache: A Randomized Clinical Trial
Who cites it
14 citing papers in PubMed.
- Disease-Related Factors Associated with Acupuncture Response in Patients with Chronic Tension-Type Headache: A Secondary Analysis of A Randomized Controlled Trial.Chinese journal of integrative medicine · 2024Trial
- Pressure Pain Thresholds Across Nerve-Related and Muscular Sites in Frequent Episodic Tension-Type Headache: An Exploratory Case-Control Study.Journal of clinical medicine · 2026Article
- Symptom clusters and network analysis in lung cancer patients receiving taxane-based chemotherapy: a comprehensive assessment using the CIPNAT multi-scale tool.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Pressure Pain Threshold Cut-Off Points at Trigeminal and Extra-Trigeminal Nervous and Musculoskeletal Structures to Discriminate Patients with Migraine from Episodic Tension-Type Headache: A Diagnostic Accuracy Study.Diagnostics (Basel, Switzerland) · 2026Article
- Network analysis of symptom clusters and core symptom changes in nasopharyngeal cancer survivors: a longitudinal study.Journal of cancer survivorship : research and practice · 2026Article
- Identifying the heterogeneity of self-advocacy in Chinese patients with breast cancer using latent profile analysis and symptom networks.Asia-Pacific journal of oncology nursing · 2025Article
- Understanding the Associations between Executive Function and Psychological Variables in Fibromyalgia Syndrome: A Network Analysis Approach.Healthcare (Basel, Switzerland) · 2024Article
- Symptom cluster among cancer survivors from a nationally representative survey: a network analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Article
- Pain intensity and psychological distress show different associations with interference and lack of life control: A clinical registry-based cohort study of >40,000 chronic pain patients from SQRP.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Network Analysis Reveals That Headache-Related, Psychological and Psycho-Physical Outcomes Represent Different Aspects in Women with Migraine.Diagnostics (Basel, Switzerland) · 2022Article
- Analyzing the Interaction between Clinical, Neurophysiological and Psychological Outcomes Underlying Chronic Plantar Heel Pain: A Network Analysis Study.International journal of environmental research and public health · 2022Article
- Network Analysis for Better Understanding the Complex Psycho-Biological Mechanisms behind Fibromyalgia Syndrome.Diagnostics (Basel, Switzerland) · 2022Article
- Understanding Sensitization, Cognitive and Neuropathic Associated Mechanisms behind Post-COVID Pain: A Network Analysis.Diagnostics (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEvidence supports that tension-type headache (TTH) involves complex underlying mechanisms. The current study aimed to quantify potential multivariate relationships between headache-related, psychophysical, psychological and health-related variables in patients with TTH using network analysis.
methodsDemographic (age, height, weight), headache-related (intensity, frequency, duration, and headache-related disability), psychological and emotional (Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Index), psycho-physical (pressure pain thresholds [PPTs] and myofascial trigger points) and health-related variables (SF-36 questionnaire) were collected in 169 TTH patients. Network connectivity analysis was unsupervised conducted to quantify the adjusted correlations between the modelled variables and to assess their centrality indices (i.e., the connectivity with other symptoms in the network and the importance in the modelled network).
resultsThe connectivity network showed local associations between psychophysical and headache-related variables. Multiple significant local positive correlations between PPTs were observed, being the strongest weight between PPTs over the cervical spine and temporalis area ([Formula: see text]: 0.41). The node with the highest strength, closeness and betweenness centrality was depressive levels. Other nodes with high centrality were vitality and headache intensity. DISCUSSION: This is the first study applying a network analysis to understand the connections between headache-related, psychophysical, psychological and health-related variables in TTH. Current findings support a model on how the variables are connected, albeit in separate clusters. The role of emotional aspects, such as depression, is supported by the network. Clinical implications of the findings, such as developing TTH treatments strategies targeting these most important variables, are discussed.
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Registered trials
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