Observational studyClinical research in cardiology : official journal of the German Cardiac Society2022
Morbidity and mortality in adults with congenital heart defects in the third and fourth life decade.
Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Congenital heart disease in 22q11.2 deletion syndrome: a meta-analysis and systematic review of the literature.Journal of medical genetics · 2025Pooled it
- Health Care Utilization in Adults With Congenital Heart Disease: Population-Based Findings.Birth defects research · 2026Article
- Anesthesia during cesarean section in women with congenital heart disease : Experience from a certified university hospital for adults with congenital heart disease in Germany-Retrospective analysis from 2013-2023.Die Anaesthesiologie · 2026Article
- Body plethysmography - additional information on exercise capacity in patients with congenital heart disease?Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Mortality rates in adults with severe congenital heart disease: insights from the National Congenital Heart Disease Registry of Australia.International journal of cardiology. Congenital heart disease · 2025Article
- Placental Malperfusion Is Associated With Adverse Outcomes in Congenital Heart Disease and With Genetic Variants in Placental Developmental Pathways.Journal of the American College of Cardiology · 2025Article
- Mortality among individuals with congenital malformations who reach adulthood: long-term follow-up of the Jerusalem Perinatal Study cohort.International journal of epidemiology · 2025Article
- Article
- Excellent medium to long term outcomes after cardiac surgery for moderate and complex congenital heart disease, regardless of geographic location.International journal of cardiology. Congenital heart disease · 2025Article
- One Ventricle, 3000 Proteins: Unraveling the Molecular Landscape of the Fontan Circulation.Journal of the American Heart Association · 2025Article
- Applications of Computational Fluid Dynamics in Congenital Heart Disease: A Review.Journal of cardiovascular development and disease · 2025Review
- A Generalized Machine Learning Model for Identifying Congenital Heart Defects (CHDs) Using ICD Codes.Birth defects research · 2025Article
- Contemporary Management of the Failing Fontan.Journal of clinical medicine · 2024Review
- Fate After the Mustard Procedure for d-Transposition of the Great Arteries: Impact of Age, Complexity, and Atrial Tachyarrhythmias: A Single Center Experience.Pediatric cardiology · 2023Article
- A machine learning model for predicting congenital heart defects from administrative data.Birth defects research · 2023Article
- Survival From Birth Until Young Adulthood Among Individuals With Congenital Heart Defects: CH STRONG.Circulation · 2023Article
- Algorithmic complexity stratification for congenital heart disease patients.International journal of cardiology. Congenital heart disease · 2023Article
- Predictors of Developing Heart Failure in Adults with Congenital Heart Defects.Reviews in cardiovascular medicine · 2023Article
- Outcomes of malignancy in adults with congenital heart disease: a single center experience.Cardio-oncology (London, England) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectivesThe population of adults with congenital heart defects (ACHD) is continuously growing. Data on morbidity and mortality of ACHD are limited. This longitudinal observational study examined a group of ACHD with surgically corrected or palliated congenital heart defects (CHD) during a 15-year period.
methodsACHD that had participated in the initial study were invited for a follow-up examination. Mortality and hospitalization data were compared with a healthy control group.
resultsFrom 05/2017 to 04/2019 a total of 249/364 (68%) ACHD participated in the follow-up study: 21% had mild, 60% moderate and 19% severe CHD. During the observational period, 290 health incidents occurred (cardiac catheterization 37%, cardiovascular surgery 27%, electrophysiological study/ablation 20%, catheter interventional treatment 14%, non-cardiac surgery 3%). Events were more frequent in ACHD with moderate (53%) and severe (87%) compared to those with mild CHD (p < 0.001). 24 individuals died at a median age of 43 years during the observation period. 29% of them had moderate and 71% severe CHD corresponding to a mortality rate of 0%, 0.29% and 1.68% per patient-year in ACHD with mild, moderate and severe CHD. Long-term survival was significantly reduced in patients with severe CHD in comparison to individuals with mild and moderate CHD (p < 0.001).
conclusionAfter correction or palliation of CHD, there was remarkable ongoing morbidity and mortality in ACHD patients over the 15-year observation period, particularly in individuals with moderate and severe CHD when compared with the general population. Thus, life-long special care is required for all surgically corrected or palliated ACHD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.