Evidence map›Paper›PMID 35229046›Full record

ReviewHealth science reports2022

The role of NK and NKT cells in the pathogenesis and improvement of multiple sclerosis following disease-modifying therapies.

Alireza Ahmadi, Zahra Fallah Vastani, Mahdi Abounoori, Mahdieh Azizi, Alireza Labani-Motlagh, Sajad Mami, Sanaz Mami

Open access · goldAbstract readReview
In one paragraph

Review in Health science reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Natural killer cells in multiple sclerosis: foe or friends?Frontiers in cellular neuroscience · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Alireza AhmadiStudent Research Committee, Department of Laboratory Sciences, Faculty of Allied Medical Sciences Ilam University of Medical Sciences Ilam Iran.
Zahra Fallah VastaniStudent Research Committee, Department of Laboratory Sciences, Faculty of Allied Medical Sciences Ilam University of Medical Sciences Ilam Iran.ORCID https://orcid.org/0000-0001-9369-8011
Mahdi AbounooriStudent Research Committee, School of Medicine Mazandaran University of Medical Sciences Sari Iran.
Mahdieh AziziDepartment of Immunology, School of Medicine Isfahan University of Medical Sciences Isfahan Iran.
Alireza Labani-MotlaghDepartment of Pulmonary Immunology The University of Texas Health Science Center at Tyler Texas USA.
Sajad MamiDepartment of laboratory and clinical science, faculty of veterinary medicine Ilam University Ilam Iran.
Sanaz MamiDepartment of Immunology, School of Medicine Ilam University of Medical Sciences Ilam Iran.
Medical University of Ilam · IRIsfahan University of Medical Sciences · IRMazandaran University of Medical Sciences · IRThe University of Texas Health Science Center at Tyler · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS) that T cells become autoreactive by recognizing CNS antigens. Both innate and adaptive immune systems are involved in the pathogenesis of MS. In recent years, the impact of innate immune cells on MS pathogenesis has received more attention. CD56

aimWe aimed to evaluate the influence of MS therapeutic agents on NK and NKT cells and NK cell subtypes. MATERIALS AND

methodsThe possible mechanism of each MS therapeutic agent has been presented here, focusing on the effects of different disease-modifying therapies on the number of NK and NKT subtypes.

resultsExpansion of CD56

conclusionExpansion of CD56

Indexed as

immunotherapymultiple sclerosisnatural killer cellsnature killer T cells

Identifiers

PMID35229046
PMCPMC8865072
OpenAlexW4206942103

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.