Evidence map›Paper›PMID 35229017›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2022

Population attributable fraction of modifiable risk factors for dementia in Chile.

Rodrigo C Vergara, Pedro Zitko, Andrea Slachevsky, Consuelo San Martin, Carolina Delgado

Erratum issuedAbstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Designing a communication strategy to promote Alzheimer's disease prevention: The CULTIVAMENTE campaign.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Rodrigo C VergaraDepartamento de Kinesiología Facultad de Artes y Educación Física Universidad Metropolitana de Ciencias de la Educación Santiago Chile.
Pedro ZitkoHealth Service & Population Research Department IoPPN King's College London London UK.
Andrea SlachevskyCentro de Gerociencia Salud Mental y Metabolismo (GERO) Santiago Chile.
Consuelo San MartinDepartamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago Chile.
Carolina DelgadoDepartamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago Chile.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionProjected dementia incidence in Latin America and the Caribbean for the next decades is overwhelming. Access to local data, stratified by sex, is imperative for planning precise dementia-prevention strategies.

methodsWe analyzed the individual and overall weighted population attributable fraction (PAF) of nine modifiable risk factors for dementia, in dementia-free subjects ≥45-years-old, using the 2016-2017 Chilean National Health Survey.

resultsThe overall weighted PAF for modifiable risk factors was 45.8% (42.2% to 49.3%). Variables with the highest PAF were lower education, high blood pressure, hearing loss, and obesity. Women showed a greater overall weighted PAF: 50.7% (45.3% to -56.1%), compared to men: 40.2% (35.4% to 45.0%), driven by a higher PAF for physical inactivity and depression in women. DISCUSSION: The PAF for modifiable risk factors for dementia in Chile is higher than in previous world reports, due to a greater prevalence of cardiovascular risk factors. Women have a higher potential for dementia prevention. HIGHLIGHTS: The proportion of dementia associated to modifiable risk factors in Chile is 45.8%.The main modifiable risk factors are high blood pressure, obesity, and hearing loss.Women had a greater prevalence of physical inactivity and depression than men.Chile had a greater prevalence of metabolic risk factors than other world regions.

Indexed as

cardiovasculardementiadepressionhypertensionLatin America and the Caribbeanmidlifemodifiable risk factorsobesityphysical inactivitypopulation attributable fractionprevention

Identifiers

PMID35229017
PMCPMC8864720

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.