Evidence map›Paper›PMID 35229016›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2022

Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non-Hispanic Whites: The HABLE study.

Kevin S King, Raul M Vintimilla, Meredith N Braskie, Ke Wei, James R Hall, Matt Borzage, Leigh A Johnson, Kristine Yaffe, Arthur W Toga, Sid E O'Bryant and 1 more

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  7. Review
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  9. Impact of white matter hyperintensity volume on cognition among US Mexican American adults.Journal of the International Neuropsychological Society : JINS · 2024
    Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Kevin S KingDepartment of Neuroradiology Barrow Neurological Institute Phoenix Arizona USA.
Raul M VintimillaInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Meredith N BraskieImaging Genetics Center Keck School of Medicine USC Stevens Neuroimaging and Informatics Institute Los Angeles California USA.
Ke WeiDepartment of Computer Science University of Southern California Los Angeles California USA.
James R HallInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Matt BorzageResearch Pediatrics Children's Hospital of Los Angeles Keck School of Medicine USC Los Angeles California USA.
Leigh A JohnsonInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Kristine YaffeDepartment of Psychiatry, Neurology, and Epidemology and Biostatistics University of California San Francisco California USA.
Arthur W TogaLaboratory of Neuro Imaging USC Stevens Neuroimaging and Informatics Institute Keck School of Medicine of USC University of Southern California Los Angeles California USA.
Sid E O'BryantInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
HABLE Study Team
University of North Texas Health Science Center · USUniversity of Southern California · USBarrow Neurological Institute · USChildren's Hospital of Los Angeles · USImaging Center · USSan Francisco VA Medical Center · US

Funding

The Health & Aging Brain Study - Health Disparities (HABS-HD)U19AG078109 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI LEIGH A JOHNSON, Sid E O'Bryant · 2022 to 2026
$181.1M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican AmericansR01AG054073 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E, TOGA, ARTHUR W · 2017 to 2021
$12.6M
Population Based Research for Alzheimer's Innovation (POP BRAIN)R35AG071916 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YAFFE, KRISTINE · 2021 to 2024
$3.8M
NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG054073NIA NIH HHS R35 AG071916NIA NIH HHS U19 AG078109
6 · The paper itself

Abstract

introductionAmong vascular risk factors we hypothesized that an increased prevalence of diabetes in Hispanics would be associated with greater white matter hyperintensity (WMH) volume, which may contribute to cognitive decline.

methodsA total of 1318 participants (60% female; 49% Hispanic, 51% non-Hispanic White; age 66.2 ± 8.9 years) underwent clinical evaluation and brain magnetic resonance imaging (MRI). WMH volume associations were assessed with age, sex, and ethnicity and then with vascular risk factors in a selective regression model.

resultsWMH volume was greater with older age ( DISCUSSION: WMH volume was greater in Hispanics, which may be partly explained by increased WMH volume related to elevated HbA1c among Hispanics but not non-Hispanic Whites.

Indexed as

cerebral microvascular diseasediabetesHispanicleukoaraiosiswhite matter hyperintensity

Identifiers

PMID35229016
PMCPMC8865739
OpenAlexW4213215658

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.