Evidence map›Paper›PMID 35228644›Full record

ArticleCommunications biology2022

Unraveling the hidden temporal range of fast β

Ashwin Balakrishnan, Katherina Hemmen, Susobhan Choudhury, Jan-Hagen Krohn, Kerstin Jansen, Mike Friedrich, Gerti Beliu, Markus Sauer, Martin J Lohse, Katrin G Heinze

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ashwin Balakrishnan *Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany.ORCID http://orcid.org/0000-0003-4059-8345
Katherina Hemmen *Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany.ORCID http://orcid.org/0000-0003-1852-6513
Susobhan ChoudhuryRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany.
Jan-Hagen KrohnRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany.ORCID http://orcid.org/0000-0002-7383-3535
Kerstin JansenRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany.
Mike FriedrichRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany.
Gerti BeliuRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany.ORCID http://orcid.org/0000-0003-1862-7912
Markus SauerRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany.ORCID http://orcid.org/0000-0002-1692-3219
Martin J LohseMax Delbrück Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125, Berlin, Germany. lohse@toxi.uni-wuerzburg.de.ORCID http://orcid.org/0000-0002-0599-3510
Katrin G HeinzeRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany. katrin.heinze@virchow.uni-wuerzburg.de.ORCID http://orcid.org/0000-0003-2372-6800

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) SA829/19-1Deutsche Forschungsgemeinschaft (German Research Foundation) TRR166, C06
6 · The paper itself

Abstract

G-protein-coupled receptors (GPCRs) are hypothesized to possess molecular mobility over a wide temporal range. Until now the temporal range has not been fully accessible due to the crucially limited temporal range of available methods. This in turn, may lead relevant dynamic constants to remain masked. Here, we expand this dynamic range by combining fluorescent techniques using a spot confocal setup. We decipher mobility constants of β

Indexed as

Membrane ProteinsSignal TransductionCell MembraneSpectrometry, FluorescenceMembrane Proteins

Identifiers

PMID35228644
PMCPMC8885909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.