Evidence map›Paper›PMID 35228613›Full record

ArticleScientific reports2022

Intra-topic latency as an automated behavioral marker of treatment response in autism spectrum disorder.

Elizabeth P McKernan, Manoj Kumar, Adriana Di Martino, Lisa Shulman, Alexander Kolevzon, Catherine Lord, Shrikanth Narayanan, So Hyun Kim

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Expressive Language Sample Concordance With ADOS-2 Scores: Autism, Down Syndrome, Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2026
    Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elizabeth P McKernanDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Manoj KumarMing Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, USA.
Adriana Di MartinoChild Mind Institute, New York, NY, USA.
Lisa ShulmanDepartment of Pediatrics, Albert Einstein College of Medicine, New York, NY, USA.
Alexander KolevzonSeaver Autism Center for Research and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Catherine LordSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Shrikanth NarayananMing Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, USA.
So Hyun KimDepartment of Psychiatry, Weill Cornell Medicine, New York, NY, USA. sok2015@med.cornell.edu.

Funding

SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Julie Secombe · 2021 to 2026
$7.0M
NICHD NIH HHS P50 HD105352
6 · The paper itself

Abstract

Data science advances in behavioral signal processing and machine learning hold the promise to automatically quantify clinically meaningful behaviors that can be applied to a large amount of data. The objective of this study was to identify an automated behavioral marker of treatment response in social communication in children with autism spectrum disorder (ASD). First, using an automated computational method, we successfully derived the amount of time it took for a child with ASD and an adult social partner (N pairs = 210) to respond to each other while they were engaged in conversation bits ("latency") using recordings of brief, natural social interactions. Then, we measured changes in latency at pre- and post-interventions. Children with ASD who were receiving interventions showed significantly larger reduction in latency compared to those who were not receiving interventions. There was also a significant group difference in the changes in latency for adult social partners. Results suggest that the automated measure of latency derived from natural social interactions is a scalable and objective method to quantify treatment response in children with ASD.

Indexed as

Autism Spectrum DisorderChildCommunicationHumans

Identifiers

PMID35228613
PMCPMC8885715

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.