ArticleScientific reports2022
Distinct alterations in cerebellar connectivity with substantia nigra and ventral tegmental area in Parkinson's disease.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Neuromodulatory Effects of Substantia Nigra Pars Reticulata Deep Brain Stimulation (SNr-DBS) in the 6-Hydroxydopamine Rat Model of Parkinson's Disease.Medicina (Kaunas, Lithuania) · 2026Article
- Prior novelty invigorates future mesolimbic target detection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Prior Novelty Invigorates Future Mesolimbic Target Detection.bioRxiv : the preprint server for biology · 2025Article
- Sketching a Space of Brain States.Neuroinformatics · 2025Article
- Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD.Journal of neurodevelopmental disorders · 2025Article
- Personalized auditory cues improve gait in patients with early Parkinson's disease.Frontiers in neurology · 2025Article
- Optimized use of safinamide as an add-on therapy in Asian patients with Parkinson's disease: a narrative review and expert opinion.Therapeutic advances in neurological disorders · 2025Review
- Functional remapping in networks of the Parkinsonian brain: A preclinical neuroimaging perspective with clinical correlates.Translational neuroscience · 2025Review
- Cerebellum mitochondrial DNA copy number is increased in Parkinson's disease.Brain communications · 2025Article
- Cerebellar Structural and N-Acetylaspartate, Choline, and Creatine Metabolic Profiles in Parkinson's Disease and Essential Tremor.Diagnostics (Basel, Switzerland) · 2024Article
- An fMRI Dataset on Social Reward Processing and Decision Making in Younger and Older Adults.Scientific data · 2024Article
- Neurobiological mechanism of music improving gait disorder in patients with Parkinson's disease: a mini review.Frontiers in neurology · 2024Review
- A missing link in affect regulation: the cerebellum.Social cognitive and affective neuroscience · 2022Review
- Cerebellar Contributions to the Basal Ganglia Influence Motor Coordination, Reward Processing, and Movement Vigor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- Structure, Function, and Genetics of the Cerebellum in Autism.Journal of psychiatry and brain science · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In Parkinson's disease (PD), neurodegeneration of dopaminergic neurons occurs in the midbrain, specifically targeting the substantia nigra (SN), while leaving the ventral tegmental area (VTA) relatively spared in early phases of the disease. Although the SN and VTA are known to be functionally dissociable in healthy adults, it remains unclear how this dissociation is altered in PD. To examine this issue, we performed a whole-brain analysis to compare functional connectivity in PD to healthy adults using resting-state functional magnetic resonance imaging (rs-fMRI) data compiled from three independent datasets. Our analysis showed that across the sample, the SN had greater connectivity with the precuneus, anterior cingulate gyrus, and areas of the occipital cortex, partially replicating our previous work in healthy young adults. Notably, we also found that, in PD, VTA-right cerebellum connectivity was higher than SN-right cerebellum connectivity, whereas the opposite trend occurred in healthy controls. This double dissociation may reflect a compensatory role of the cerebellum in PD and could provide a potential target for future study and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.