ArticleNature communications2022
SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism.eLife · 2026Article
- Metabolite profiling of the effect of prenatal stimuli across postnatal treatments in the liver.Molecular and cellular endocrinology · 2026Article
- ROS-responsive cellular vesicles with ferroptosis-targeting siACMSD delivery for acute kidney injury therapy.Theranostics · 2026Article
- Adipose-Specific Cytokines as Modulators of Reproductive Activity.Biomedicines · 2025Review
- Reciprocal oscillation and host-microbial communication in liver metabolic control.Gut microbes · 2025Review
- Targeting hepatocyte-specific SLC2A8 blocks hepatic steatosis and dissociates TCA cycle flux inhibition from glutamine anaplerosis.Hepatology communications · 2025Article
- The Role of NADAmerican journal of cardiovascular drugs : drugs, devices, and other interventions · 2025Review
- Dapagliflozin targets SGLT2/SIRT1 signaling to attenuate the osteogenic transdifferentiation of vascular smooth muscle cells.Cellular and molecular life sciences : CMLS · 2024Article
- Hepatocyte MMP14 mediates liver and inter-organ inflammatory responses to diet-induced liver injury.PNAS nexus · 2024Article
- The Impact of the Endocrine and Immunological Function of Adipose Tissue on Reproduction in Women with Obesity.International journal of molecular sciences · 2024Review
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function.Current issues in molecular biology · 2024Article
- Exploring histone deacetylases in type 2 diabetes mellitus: pathophysiological insights and therapeutic avenues.Clinical epigenetics · 2024Review
- The use of a systems approach to increase NADnpj aging · 2024Article
- Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease.Development (Cambridge, England) · 2023Article
- The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes.The Journal of biological chemistry · 2023Article
- Role of Liver CD38 in the Regulation of Metabolic Pathways during Cold-Induced Thermogenesis in Mice.Cells · 2022Article
- Exploring the Multi-Faceted Role of Sirtuins in Glioblastoma Pathogenesis and Targeting Options.International journal of molecular sciences · 2022Review
- Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Cassandra B HigginsDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Allyson L MayerBiogenerator, St. Louis, MO, 63110, USA.
Yiming ZhangDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, 63110, USA.ORCID http://orcid.org/0000-0002-6020-0237
Michael FranczykDepartment of Medicine, Keio University School of Medicine, Minato, Tokyo, Japan.
Samuel BallentineDepartment of Anatomic and Molecular Pathology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Jun YoshinoDepartment of Medicine, Keio University School of Medicine, Minato, Tokyo, Japan.ORCID http://orcid.org/0000-0001-9833-4356
Brian J DeBoschDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, 63110, USA. deboschb@wustl.edu.ORCID http://orcid.org/0000-0002-9924-7921
Washington University in St. Louis · USKeio University · JPBiogen (United States) · US
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI FUMIHIKO URANO · 2013 to 2026
$27.1MPediatric Gastroenterology Research Training ProgramT32DK077653 · NIDDK · WASHINGTON UNIVERSITY · PI PHILLIP I TARR · 2007 to 2026
$5.8MREGULATION OF SYSTEMIC GLUCOSE AND LIPID HOMEOSTASIS BY ADIPOCYTE NAD BIOSYNTHESISR01DK104995 · NIDDK · WASHINGTON UNIVERSITY · PI KLEIN, SAMUEL · 2016 to 2024
$3.5MTreating secondary cardiomyopathies by mimicking the adaptive hepatic glucose fasting responseR01HL147968 · NHLBI · WASHINGTON UNIVERSITY · PI DEBOSCH, BRIAN JESSE · 2020 to 2024
$3.2MLeveraging glucose transport and the adaptive fasting response to modulate hepatic metabolismR01DK126622 · NIDDK · WASHINGTON UNIVERSITY · PI DEBOSCH, BRIAN JESSE · 2021 to 2024
$1.7MBiological Effects and Mechanistic Actions of the Natural Disaccharide and Dietary Supplement, Trehalose.R21AT010520 · NCCIH · WASHINGTON UNIVERSITY · PI DEBOSCH, BRIAN JESSE · 2019 to 2020
$432kLeveraging glucose transport and the adaptive fasting response to modulate hepatic metabolismR56DK115764 · NIDDK · WASHINGTON UNIVERSITY · PI DEBOSCH, BRIAN JESSE · 2018 to 2018
$381kLeveraging arginine catabolism to treat metabolic diseasesF31DK131875 · NIDDK · WASHINGTON UNIVERSITY · PI ZHANG, YIMING · 2021 to 2024
$143kNCATS NIH HHS UL1 TR002345NCCIH NIH HHS R21 AT010520NHLBI NIH HHS R01 HL147968NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK104995NIDDK NIH HHS R01 DK126622NIDDK NIH HHS R56 DK115764NIDDK NIH HHS T32 DK077653
Abstract
Calorie restriction abates aging and cardiometabolic disease by activating metabolic signaling pathways, including nicotinamide adenine dinucleotide (NAD
Indexed as
Nicotinamide PhosphoribosyltransferaseSirtuin 1AnimalsCytokinesHepatocytesLiverMiceNADCytokinesNADNicotinamide PhosphoribosyltransferaseSirt1 protein, mouseSirtuin 1
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.