Evidence map›Paper›PMID 35228415›Full record

ArticleInternal medicine (Tokyo, Japan)2022

Aseptic Meningitis after Amenamevir Treatment for Herpes Zoster in the First Branch of the Trigeminal Nerve.

Kazuhiro Itoh, Yasuhiko Mitsuke, Mami Wakahara, Tatsuya Yoshioka, Nozomi Otsuki, Yusuke Suzuki, Chiyo Kiriba, Atsushi Kuwata, Ippei Sakamaki, Hiromichi Iwasaki and 1 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  7. Therapeutic advances in neuroinfectious diseases.Therapeutic advances in infectious disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kazuhiro ItohDepartment of Internal Medicine, National Hospital Organization Awara Hospital, Japan.
Yasuhiko MitsukeDepartment of Internal Medicine, National Hospital Organization Awara Hospital, Japan.
Mami WakaharaDepartment of Dermatology, National Hospital Organization Awara Hospital, Japan.
Tatsuya YoshiokaDepartment of Ophthalmology, National Hospital Organization Awara Hospital, Japan.
Nozomi OtsukiDepartment of Internal Medicine, National Hospital Organization Awara Hospital, Japan.
Yusuke SuzukiDepartment of Internal Medicine, National Hospital Organization Awara Hospital, Japan.
Chiyo KiribaDepartment of Internal Medicine, National Hospital Organization Awara Hospital, Japan.
Atsushi KuwataDepartment of Internal Medicine, National Hospital Organization Awara Hospital, Japan.
Ippei SakamakiDepartment of Infectious Diseases, Faculty of Medical Sciences, University of Fukui, Japan.
Hiromichi IwasakiDepartment of Infectious Diseases, Faculty of Medical Sciences, University of Fukui, Japan.
Hiroshi TsutaniDepartment of Internal Medicine, National Hospital Organization Awara Hospital, Japan.
National Hospital Organization · JPUniversity of Fukui · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amenamevir has been approved for the treatment of herpes zoster (HZ); however, its therapeutic efficacy against central nervous system (CNS) infection may be insufficient due to its low spinal fluid permeability. We herein report a case of aseptic meningitis in a 91-year-old Japanese man treated with amenamevir for HZ in the trigeminal nerve region. Several cases of CNS infection have been reported in patients receiving amenamevir treatment for HZ. Patients with CNS complications often have skin rashes near the trigeminal region. Thus, we should be alert for signs of CNS infection when administering amenamevir to patients with such rashes.

Indexed as

ExanthemaHerpes ZosterMeningitis, AsepticAged, 80 and overAntiviral AgentsHerpesvirus 3, HumanHumansMaleOxadiazolesTrigeminal NerveAntiviral AgentsASP2151Oxadiazolesamenameviraseptic meningitiscentral nervous system infectionvaricella zoster virus

Identifiers

PMID35228415
PMCPMC9556230
OpenAlexW4214700964

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.