Evidence map›Paper›PMID 35228334›Full record

ArticleNeurology2022

Carotid Intima-Media Thickness and Midlife Cognitive Function: Impact of Race and Social Disparities in the Bogalusa Heart Study.

Ileana De Anda-Duran, Camilo Fernandez Alonso, David J Libon, Owen T Carmichael, Vijaya B Kolachalama, Shakira F Suglia, Rhoda Au, Lydia A Bazzano

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ileana De Anda-DuranFrom the Department of Epidemiology (I.D.A.-D., L.A.B.), Tulane University School of Public Health and Tropical Medicine; Department of Medicine (C.F.A., L.A.B.), Tulane University School of Medicine, New Orleans, LA; Department of Psychology (D.J.L.) and New Jersey Institute for Successful Aging (D.J.L.), School of Osteopathic Medicine, Rowan University, Glassboro, NJ; Louisiana State University's Pennington Biomedical Research Centre (O.T.C.), Baton Rouge; Departments of Medicine (V.B.K.) and Anatomy and Neurobiology (R.A.), Boston University School of Medicine; Department of Computer Science and Faculty of Computing and Data Sciences (V.B.K.), Boston University, MA; Department of Epidemiology (S.F.S.), Rollins School of Public Health, Emory University, Atlanta, GA; and Boston University Alzheimer's Disease Center (R.A.), MA.
Camilo Fernandez AlonsoFrom the Department of Epidemiology (I.D.A.-D., L.A.B.), Tulane University School of Public Health and Tropical Medicine; Department of Medicine (C.F.A., L.A.B.), Tulane University School of Medicine, New Orleans, LA; Department of Psychology (D.J.L.) and New Jersey Institute for Successful Aging (D.J.L.), School of Osteopathic Medicine, Rowan University, Glassboro, NJ; Louisiana State University's Pennington Biomedical Research Centre (O.T.C.), Baton Rouge; Departments of Medicine (V.B.K.) and Anatomy and Neurobiology (R.A.), Boston University School of Medicine; Department of Computer Science and Faculty of Computing and Data Sciences (V.B.K.), Boston University, MA; Department of Epidemiology (S.F.S.), Rollins School of Public Health, Emory University, Atlanta, GA; and Boston University Alzheimer's Disease Center (R.A.), MA.
David J LibonFrom the Department of Epidemiology (I.D.A.-D., L.A.B.), Tulane University School of Public Health and Tropical Medicine; Department of Medicine (C.F.A., L.A.B.), Tulane University School of Medicine, New Orleans, LA; Department of Psychology (D.J.L.) and New Jersey Institute for Successful Aging (D.J.L.), School of Osteopathic Medicine, Rowan University, Glassboro, NJ; Louisiana State University's Pennington Biomedical Research Centre (O.T.C.), Baton Rouge; Departments of Medicine (V.B.K.) and Anatomy and Neurobiology (R.A.), Boston University School of Medicine; Department of Computer Science and Faculty of Computing and Data Sciences (V.B.K.), Boston University, MA; Department of Epidemiology (S.F.S.), Rollins School of Public Health, Emory University, Atlanta, GA; and Boston University Alzheimer's Disease Center (R.A.), MA.
Owen T CarmichaelFrom the Department of Epidemiology (I.D.A.-D., L.A.B.), Tulane University School of Public Health and Tropical Medicine; Department of Medicine (C.F.A., L.A.B.), Tulane University School of Medicine, New Orleans, LA; Department of Psychology (D.J.L.) and New Jersey Institute for Successful Aging (D.J.L.), School of Osteopathic Medicine, Rowan University, Glassboro, NJ; Louisiana State University's Pennington Biomedical Research Centre (O.T.C.), Baton Rouge; Departments of Medicine (V.B.K.) and Anatomy and Neurobiology (R.A.), Boston University School of Medicine; Department of Computer Science and Faculty of Computing and Data Sciences (V.B.K.), Boston University, MA; Department of Epidemiology (S.F.S.), Rollins School of Public Health, Emory University, Atlanta, GA; and Boston University Alzheimer's Disease Center (R.A.), MA.ORCID 0000-0002-0576-0047
Vijaya B KolachalamaFrom the Department of Epidemiology (I.D.A.-D., L.A.B.), Tulane University School of Public Health and Tropical Medicine; Department of Medicine (C.F.A., L.A.B.), Tulane University School of Medicine, New Orleans, LA; Department of Psychology (D.J.L.) and New Jersey Institute for Successful Aging (D.J.L.), School of Osteopathic Medicine, Rowan University, Glassboro, NJ; Louisiana State University's Pennington Biomedical Research Centre (O.T.C.), Baton Rouge; Departments of Medicine (V.B.K.) and Anatomy and Neurobiology (R.A.), Boston University School of Medicine; Department of Computer Science and Faculty of Computing and Data Sciences (V.B.K.), Boston University, MA; Department of Epidemiology (S.F.S.), Rollins School of Public Health, Emory University, Atlanta, GA; and Boston University Alzheimer's Disease Center (R.A.), MA.ORCID 0000-0002-5312-8644
Shakira F SugliaFrom the Department of Epidemiology (I.D.A.-D., L.A.B.), Tulane University School of Public Health and Tropical Medicine; Department of Medicine (C.F.A., L.A.B.), Tulane University School of Medicine, New Orleans, LA; Department of Psychology (D.J.L.) and New Jersey Institute for Successful Aging (D.J.L.), School of Osteopathic Medicine, Rowan University, Glassboro, NJ; Louisiana State University's Pennington Biomedical Research Centre (O.T.C.), Baton Rouge; Departments of Medicine (V.B.K.) and Anatomy and Neurobiology (R.A.), Boston University School of Medicine; Department of Computer Science and Faculty of Computing and Data Sciences (V.B.K.), Boston University, MA; Department of Epidemiology (S.F.S.), Rollins School of Public Health, Emory University, Atlanta, GA; and Boston University Alzheimer's Disease Center (R.A.), MA.ORCID 0000-0002-5634-9290
Rhoda AuFrom the Department of Epidemiology (I.D.A.-D., L.A.B.), Tulane University School of Public Health and Tropical Medicine; Department of Medicine (C.F.A., L.A.B.), Tulane University School of Medicine, New Orleans, LA; Department of Psychology (D.J.L.) and New Jersey Institute for Successful Aging (D.J.L.), School of Osteopathic Medicine, Rowan University, Glassboro, NJ; Louisiana State University's Pennington Biomedical Research Centre (O.T.C.), Baton Rouge; Departments of Medicine (V.B.K.) and Anatomy and Neurobiology (R.A.), Boston University School of Medicine; Department of Computer Science and Faculty of Computing and Data Sciences (V.B.K.), Boston University, MA; Department of Epidemiology (S.F.S.), Rollins School of Public Health, Emory University, Atlanta, GA; and Boston University Alzheimer's Disease Center (R.A.), MA.ORCID 0000-0001-7742-4491
Lydia A BazzanoFrom the Department of Epidemiology (I.D.A.-D., L.A.B.), Tulane University School of Public Health and Tropical Medicine; Department of Medicine (C.F.A., L.A.B.), Tulane University School of Medicine, New Orleans, LA; Department of Psychology (D.J.L.) and New Jersey Institute for Successful Aging (D.J.L.), School of Osteopathic Medicine, Rowan University, Glassboro, NJ; Louisiana State University's Pennington Biomedical Research Centre (O.T.C.), Baton Rouge; Departments of Medicine (V.B.K.) and Anatomy and Neurobiology (R.A.), Boston University School of Medicine; Department of Computer Science and Faculty of Computing and Data Sciences (V.B.K.), Boston University, MA; Department of Epidemiology (S.F.S.), Rollins School of Public Health, Emory University, Atlanta, GA; and Boston University Alzheimer's Disease Center (R.A.), MA.ORCID 0000-0002-8958-1352
Tulane University · US

Funding

Lifespan Cardiovascular Risk Exposures and Alzheimer-related brain health: Bogalusa Heart StudyRF1AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2019 to 2022
$4.2M
Supplemental Funding Request for RF1 AG062309 Early life glycemic status and Alzheimer's disease neuroimaging markers in middle age: the Bogalusa Heart StudyR01AG062309 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2019 to 2023
$3.9M
Cognitive Heterogeneity in those with high Alzheimer's Disease RiskRF1AG062109 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 2020 to 2021
$1.8M
Cognitive heterogeneity in those with high Alzheimer's Disease RiskR56AG062109 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 2018 to 2018
$517k
NIA NIH HHS R01 AG062309NIA NIH HHS R56 AG062109NIA NIH HHS RF1 AG041200NIA NIH HHS RF1 AG062109
6 · The paper itself

Abstract

BACKGROUND AND

objectivesCarotid intima-media thickness (c-IMT) is a measurement of atherosclerosis, a progressive disease that develops as early as childhood and has been linked with cognitive impairment and dementia in the elderly. However, the relationship between c-IMT and midlife cognitive function and the race and social disparities in this relationship remain unclear. We examined the association between c-IMT and cognitive function in midlife among Black and White participants from a semirural community-based cohort in Bogalusa, Louisiana.

methodsIn this cross-sectional analysis of participants from the Bogalusa Heart Study, linear regression models were used to determine the association between c-IMT dichotomized above the 50th percentile (>0.87 mm), an a demographically standardized global cognitive score (GCS), and individual cognitive domain-based

resultsA total of 1,217 participants (age 48 ± 5.28 years) were included; 66% (804) self-identified as White, and 34% (413) self-identified as Black. Of those, 58% (708) were women, and 42% (509) were men. Having a c-IMT ≥50th percentile was inversely associated with GCS ( DISCUSSION: Subclinical atherosclerosis, measured as c-IMT, was associated with worse midlife cognitive function, independently of major CVRFs. The association was buffered by education and may be stronger among Black than White participants, likely due to corresponding structural and social determinants. These findings underscore the importance of establishing preventive measures in midlife and suggest subclinical atherosclerosis as a potential target to prevent cognitive decline.

Indexed as

AtherosclerosisCarotid Intima-Media ThicknessAdultAgedChildCognitionCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedRisk FactorsWhite People

Identifiers

PMID35228334
PMCPMC9109147
OpenAlexW4214568013

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.