Evidence map›Paper›PMID 35228279›Full record

ArticleBMJ open2022

Safety, feasibility, acceptability and preliminary effects of the Neurofenix platform for Rehabilitation via HOMe Based gaming exercise for the Upper-limb post Stroke (RHOMBUS): results of a feasibility intervention study.

Cherry Kilbride, Daniel J M Scott, Tom Butcher, Meriel Norris, Alyson Warland, Nana Anokye, Elizabeth Cassidy, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Cherry KilbrideDepartment of Health Sciences, Brunel University London, London, UK Cherry.Kilbride@brunel.ac.uk.ORCID 0000-0002-2045-1883
Daniel J M ScottDepartment of Health Sciences, Brunel University London, London, UK.
Tom ButcherDepartment of Health Sciences, Brunel University London, London, UK.
Meriel NorrisDepartment of Health Sciences, Brunel University London, London, UK.
Alyson WarlandDepartment of Health Sciences, Brunel University London, London, UK.
Nana AnokyeDepartment of Health Sciences, Brunel University London, London, UK.
Elizabeth CassidyFreelance Academic and Research Supervisor, London, UK.
Karen BakerDepartment of Health Sciences, Brunel University London, London, UK.
Dimitrios A AthanasiouNeurofenix, London, UK.
Guillem Singla-BuxarraisNeurofenix, London, UK.
Alexander NowickyDepartment of Health Sciences, Brunel University London, London, UK.
Jennifer RyanDepartment of Health Sciences, Brunel University London, London, UK.
Brunel University of London · GBRoyal College of Surgeons in Ireland · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the safety, feasibility and acceptability of the Neurofenix platform for home-based rehabilitation of the upper limb (UL).

designA non-randomised intervention design with a parallel process evaluation.

settingParticipants' homes, South-East England.

participantsThirty adults (≥18 years), minimum 12-week poststroke, not receiving UL rehabilitation, scoring 9-25 on the Motricity Index (elbow and shoulder), with sufficient cognitive and communicative abilities to participate.

interventionsParticipants were trained to use the platform, followed by 1 week of graded game-play exposure and 6-week training, aiming for a minimum 45 min, 5 days/week. OUTCOMES: Safety was determined by assessing pain and poststroke fatigue at 8 and 12 weeks, and adverse events (AEs). Impairment, activity and participation outcomes were measured. Intervention feasibility was determined by the amount of specialist training and support required to complete the intervention, time and days spent training, and number of UL movements performed. Acceptability was assessed by a satisfaction questionnaire and semistructured interviews.

resultsParticipants (14 women; mean (SD) age 60.0 (11.3) years) were a median of 4.9 years poststroke (minimum-maximum: 1-28 years). Twenty-seven participants completed the intervention. The odds of having shoulder pain were lower at 8 weeks (OR 0.45, 95% CI 0.24 to 0.83, p=0.010) and 12 weeks (OR 0.46, 95% CI 0.25 to 0.86, p=0.014) compared with baseline. Fugl-Meyer upper extremity, Motor Activity Log and passive range of movement improved. No other gains were recorded. Poststroke fatigue did not change. Thirty mild and short-term AEs and one serious (unrelated) AE were reported by 19 participants. Participants trained with the platform for a median of 17.4 hours over 7 weeks (minimum-maximum: 0.3-46.9 hours), equating to a median of 149 min per week. The median satisfaction score was 36 out of 40.

conclusionThe Neurofenix platform is a safe, feasible and well accepted way to support UL training for people at least three months poststroke. TRIAL REGISTRATION NUMBER: ISRCTN60291412.

Indexed as

StrokeStroke RehabilitationVideo GamesAdultFeasibility StudiesFemaleHumansMiddle AgedTreatment OutcomeUpper Extremityadult neurologyrehabilitation medicinestroke

Identifiers

PMID35228279
PMCPMC8886425
OpenAlexW4214710748

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.