Evidence map›Paper›PMID 35227908›Full record

ReviewJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2022

Thymic Carcinomas-A Concise Multidisciplinary Update on Recent Developments From the Thymic Carcinoma Working Group of the International Thymic Malignancy Interest Group.

Anja C Roden, Usman Ahmad, Giuseppe Cardillo, Nicolas Girard, Deepali Jain, Edith M Marom, Alexander Marx, Andre L Moreira, Andrew G Nicholson, Arun Rajan and 6 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. PRRC2A-mediated mCell death & disease · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Fe metal-organic framework-derived heterojunction for metabolic diagnosis of thymic epithelial tumor.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 7 countries.

Anja C RodenDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. Electronic address: roden.anja@mayo.edu.
Usman AhmadDepartment of Cardiothoracic Surgery, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.
Giuseppe CardilloDepartment of Thoracic Surgery, Carlo Forlanini Hospital, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy.
Nicolas GirardInstitut Curie, Institut du thorax Curie Montsouris, Paris, France; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Paris Saclay Campus, Versailles, France.
Deepali JainDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, India.
Edith M MaromRadiology Department, The Chaim Sheba Medical Center Affiliated With Tel Aviv University, Tel Aviv, Israel.
Alexander MarxInstitute of Pathology, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany.
Andre L MoreiraDepartment of Pathology, New York University Langone Health, New York, New York.
Andrew G NicholsonDepartment of Histopathology, Royal Brompton and Harefield Hospitals, London, United Kingdom; National Heart and Lung Institute, Imperial College, London, United Kingdom.
Arun RajanThoracic and Gastrointestinal Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Annemarie F ShepherdDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Charles B SimoneDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center and New York Proton Center, New York, New York.
Chad D StrangeDivision of Diagnostic Imaging, MD Anderson Cancer Center, Houston, Texas.
Malgorzata SzolkowskaDepartment of Pathology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
Mylene T TruongDivision of Diagnostic Imaging, MD Anderson Cancer Center, Houston, Texas.
Andreas RimnerDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Memorial Sloan Kettering Cancer Center · USThe University of Texas MD Anderson Cancer Center · USAll India Institute of Medical Sciences · INAzienda Ospedaliera San Camillo-Forlanini · ITCleveland Clinic · USHarefield Hospital · GBMayo Clinic · USNational Institutes of Health · USNYU Langone Health · USTel Aviv University · ILUniversité de Versailles Saint-Quentin-en-Yvelines · FRUniversity Medical Centre Mannheim · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Pilot Study of Avelumab in Thymic Epithelial TumorsZIABC011900 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI RAJAN, ARUN · 2019 to 2025
$2.9M
A Phase II Trial of PT-112 in Subjects with Thymoma and Thymic CarcinomaZIABC012106 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI RAJAN, ARUN · 2022 to 2025
$1.5M
Intramural NIH HHS Z99 CA999999NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Thymic carcinomas are rare malignancies that in general arise in the prevascular (anterior) mediastinum. These tumors are usually invasive, often present at advanced stages, and typically behave aggressively. Studies are hampered by the paucity of these tumors, the large variety of carcinoma subtypes, and the lack of unique morphologic and immunophenotypic features. Despite these challenges, advances in diagnostic imaging, surgical approaches, systemic therapies, and radiation therapy techniques have been made. The WHO classification of thymic epithelial tumors has been updated in 2021, and the eighth tumor nodal metastasis staging by the American Joint Committee on Cancer/Union for International Cancer Control included thymic carcinomas in 2017. Molecular alterations that provide more insight into the pathogenesis of these tumors and that potentially permit use of novel targeted therapies are increasingly being identified. New approaches to radiation therapy, chemotherapy, and immunotherapy are under evaluation. International societies, including the International Thymic Malignancy Interest Group, European Society of Thoracic Surgeons, and Japanese, Chinese, and Korean thymic associations, have been critical in organizing and conducting multi-institutional clinical studies. Herein, we review contemporary multidisciplinary perspectives in diagnosis and management of thymic carcinoma.

Indexed as

Lung NeoplasmsNeoplasms, Glandular and EpithelialThymomaThymus NeoplasmsHumansNeoplasm StagingPublic OpinionInternational Thymic Malignancy Interest GroupITMIGThymic carcinomaTNM stagingWHO

Identifiers

PMID35227908
PMCPMC11080660
OpenAlexW4214543331

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.