Evidence map›Paper›PMID 35227758›Full record

ArticleAntiviral research2022

Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells.

Nilanka Perera, Juliane Brun, Dominic S Alonzi, Beatrice E Tyrrell, Joanna L Miller, Nicole Zitzmann

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antiviral research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Molecules (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Nilanka PereraDepartment of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK; Department of Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka. Electronic address: nilanka@sjp.ac.lk.
Juliane BrunDepartment of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK. Electronic address: juliane.brun@path.ox.ac.uk.
Dominic S AlonziDepartment of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK. Electronic address: dominic.alonzi@ctl.ox.ac.uk.
Beatrice E TyrrellDepartment of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK. Electronic address: beatrice.tyrrell@gmail.com.
Joanna L MillerDepartment of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK. Electronic address: joanna.miller@medsci.ox.ac.uk.
Nicole ZitzmannDepartment of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK. Electronic address: Nicole.zitzmann@bioch.ox.ac.uk.
University of Oxford · GBUniversity of Sri Jayewardenepura · LK

Funding

Wellcome Trust 105402/Z/14/ZWellcome Trust 203853/Z/16/Z
6 · The paper itself

Abstract

Dendritic cells (DCs) are important targets for dengue virus (DENV) infection and play a significant role in the early immune response. Antiviral effects of iminosugars against DENV in primary cells have been demonstrated previously in monocyte-derived macrophages (MDMΦs). Given the important role played by DCs in innate immune defense against DENV, the antiviral effects of three deoxynojirimycin (DNJ) derivatives (NN-DNJ, EOO-DNJ and 2THO-DNJ) and a deoxygalactonojirimycin (DGJ) negative control were evaluated in DENV-infected primary human monocyte-derived immature DCs (imDCs). DNJ- but not DGJ-derivatives elicited antiviral activity in DENV-infected imDCs, similar to that observed in MDMΦs. The DNJ-derivatives inhibited DENV secretion in a dose-dependent manner. Endoplasmic reticulum (ER) α-glucosidase I inhibition by DNJ-derived iminosugars, at concentrations of 3.16 μM, correlated with a reduction in the specific infectivity of virions that were still secreted, as well as a reduction in DENV-induced tumour necrosis factor alpha secretion. This suggests iminosugar-mediated ER α-glucosidase I inhibition may give rise to further benefits during DENV infection, beyond the reduction in viral secretion associated with ER α-glucosidase II inhibition.

Indexed as

DengueDengue Virus1-DeoxynojirimycinAntiviral AgentsDendritic CellsEndoplasmic ReticulumHumansMacrophages1-DeoxynojirimycinAntiviral AgentsAntiviral effectsDendritic cellsDengueIminosugarsα-glucosidases

Identifiers

PMID35227758
PMCPMC9760573
OpenAlexW4214767720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.