Evidence map›Paper›PMID 35227737›Full record

ArticleJournal of molecular and cellular cardiology2022

CineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel.

D E Midgett, S L Thorn, S S Ahn, S Uman, R Avendano, I Melvinsdottir, T Lysyy, J S Kim, J S Duncan, J D Humphrey and 3 more

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular and cellular cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

D E MidgettSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States of America; Department of Biomedical Engineering, Yale University, New Haven, CT, United States of America.
S L ThornSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States of America.
S S AhnDepartment of Biomedical Engineering, Yale University, New Haven, CT, United States of America.
S UmanDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States of America.
R AvendanoSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States of America.
I MelvinsdottirSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States of America.
T LysyyDepartment of Surgery, Yale University School of Medicine, New Haven, CT, United States of America.
J S KimDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, United States of America.
J S DuncanDepartment of Biomedical Engineering, Yale University, New Haven, CT, United States of America; Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, United States of America.
J D HumphreyDepartment of Biomedical Engineering, Yale University, New Haven, CT, United States of America.
X PapademetrisDepartment of Biomedical Engineering, Yale University, New Haven, CT, United States of America; Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, United States of America.
J A BurdickDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States of America.
A J SinusasSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States of America; Department of Biomedical Engineering, Yale University, New Haven, CT, United States of America; Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, United States of America. Electronic address: albert.sinusas@yale.edu.
Yale University · USUniversity of Pennsylvania · US

Funding

q4DE: A Biomarker for Image-Guided, Post-MI Hydrogel TherapyR01HL121226 · NHLBI · YALE UNIVERSITY · PI DUNCAN, JAMES S, O'DONNELL, MATTHEW · 2014 to 2022
$6.3M
Training In Multi-modality Molecular & Translational Cardiovascular ImagingT32HL098069 · NHLBI · YALE UNIVERSITY · PI JAMES S DUNCAN, Georges El Fakhri · 2010 to 2026
$5.2M
Image Guided Delivery of Bioresponsive HydrogelsR01HL137365 · NHLBI · YALE UNIVERSITY · PI BURDICK, JASON A, DUNCAN, JAMES S · 2018 to 2021
$3.2M
Hybrid Volumetric SPECT/CT Imaging SystemS10RR025555 · NCRR · YALE UNIVERSITY · PI SINUSAS, ALBERT J · 2009 to 2009
$500k
NCRR NIH HHS S10 RR025555NHLBI NIH HHS R01 HL121226NHLBI NIH HHS R01 HL137365NHLBI NIH HHS T32 HL098069
6 · The paper itself

Abstract

Myocardial infarction (MI) produces acute changes in strain and stiffness within the infarct that can affect remote areas of the left ventricle (LV) and drive pathological remodeling. We hypothesized that intramyocardial delivery of a hydrogel within the MI region would lower wall stress and reduce adverse remodeling in Yorkshire pigs (n = 5).

Indexed as

Heart VentriclesMyocardial InfarctionAnimalsHydrogelsSwineTheranostic NanomedicineVentricular RemodelingHydrogelsHydrogelLagrangian strainLeft ventricle (LV)Myocardial infarction (MI)

Identifiers

PMID35227737
PMCPMC9035115
OpenAlexW4214633051

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.