Evidence map›Paper›PMID 35227663›Full record

ArticleChest2022

Mechanical Ventilator Liberation of Patients With COVID-19 in Long-term Acute Care Hospital.

Tamas Dolinay, Dale Jun, Lucia Chen, Jeffrey Gornbein

Open access · hybridAbstract read

In one paragraph

Article in Chest, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

0.8field-weighted citation impact, top 29% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

Randomized clinical trial of ventilator liberation with pressure support ventilation versus therapist-implement patient-specific weaning in prolonged weaning patients via tracheostomy.BMC pulmonary medicine · 2026
Trial
Development and performance assessment of a novel scroll compressor-based oxygen generator integrated ventilator.Scientific reports · 2025
Article
Ventilator Weaning in Prolonged Mechanical Ventilation-A Narrative Review.Journal of clinical medicine · 2024
Review
Epidemiology of Tracheostomized Adult Patients Admitted to Specialized Weaning Centers After Acute COVID-19.Respiratory care · 2024
Observational
Ventilatory ratio and mechanical power in prolonged mechanically ventilated COVID-19 patientsTherapeutic advances in respiratory disease
Observational

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tamas DolinayDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA; Barlow Respiratory Hospital, University of California, Los Angeles, Los Angeles, CA. Electronic address: tdolinay@mednet.ucla.edu.

Dale JunDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA; Barlow Respiratory Hospital, University of California, Los Angeles, Los Angeles, CA.

Lucia ChenDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA.

Jeffrey GornbeinDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA.

University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMechanical ventilation (MV) via tracheostomy is performed commonly for patients who are in long-term acute care hospitals (LTACHs) after respiratory failure. However, the outcome of MV in COVID-19-associated respiratory failure in LTACHs is not known. RESEARCH QUESTION: What is the ventilator liberation rate of patients who have received tracheostomy with COVID-19-associated respiratory failure compared with those with respiratory failure unrelated to COVID-19 in LTACHs? STUDY DESIGN AND

methodsIn this retrospective cohort study, we examined mechanically ventilated patients discharged between June 2020 and March 2021. Of 242 discharges, 165 patients who had undergone tracheostomy arrived and were considered for ventilator liberation. One hundred twenty-eight patients did not have COVID-19 and 37 patients were admitted for COVID-19.

resultsThe primary outcome of the study was ventilator liberation; secondary outcomes were functional recovery, length of stay (LOS) at the LTACH, and discharge disposition. After controlling for demographics, the number of comorbidities, hemodialysis, vasopressor need, thrombocytopenia, and the LOS at the short-term acute care hospital, our results indicated that patients with COVID-19 showed a higher adjusted ventilator liberation rate of 91.4% vs 56.0% in those without COVID-19. Functional ability was assessed with the change of Functional Status Score for the Intensive Care Unit (FSS-ICU) between admission and discharge. The adjusted mean change in FSS-ICU was significantly higher in the COVID-19 group than in the non-COVID-19 group: 9.49 (95% CI, 7.38-11.6) vs 2.08 (95% CI, 1.05-3.11), respectively (P < .001). Patients with COVID-19 experienced a shorter adjusted LOS at the LTACH with an adjusted hazard ratio of 1.57 (95% CI, 1.0-2.46; P = .05) compared with patients without COVID-19. We did not observe significant differences between the two groups regarding discharge location, but a trend toward need for lower level of care was found in patients with COVID-19.

interpretationOur study suggests that patients with COVID-19 requiring MV and tracheostomy have a higher chance for recovery than those without COVID-19.

Indexed as

COVID-19Respiratory InsufficiencyHospitalsHumansIntensive Care UnitsLength of StayRespiration, ArtificialRetrospective StudiesVentilators, MechanicalCOVID-19long-term acute care hospitalventilator liberation

Identifiers

PMID35227663

DOI10.1016/j.chest.2022.02.030

PMCPMC8875856

OpenAlexW4214677646

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.