Evidence map›Paper›PMID 35227662›Full record

ArticleExperimental cell research2022

Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.

Angelo Cirinelli, Justin Wheelan, Christopher Grieg, Carlos A Molina

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental cell research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Angelo CirinelliDepartment of Biology, Montclair State University, Montclair, NJ, 07043, USA; Molecular Biology and Genetics Program, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA.
Justin WheelanDepartment of Biology, Montclair State University, Montclair, NJ, 07043, USA; Environmental Science and Management Program, Montclair State University, Montclair, NJ, 07043, USA.
Christopher GriegDepartment of Biology, Montclair State University, Montclair, NJ, 07043, USA; Molecular Biology and Genetics Program, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA.
Carlos A MolinaDepartment of Biology, Montclair State University, Montclair, NJ, 07043, USA; Environmental Science and Management Program, Montclair State University, Montclair, NJ, 07043, USA. Electronic address: molinac@montclair.edu.
Montclair State University · USRutgers, The State University of New Jersey · US

Funding

Post-translational Regulation of Inducible cAMP Early Repressor and its Implications in CancerSC1GM125583 · NIGMS · MONTCLAIR STATE UNIVERSITY · PI MOLINA, CARLOS A · 2018 to 2021
$1.3M
NIGMS NIH HHS SC1 GM125583
6 · The paper itself

Abstract

ICER is a transcriptional repressor that is mono- or poly-ubiquitinated. This either causes ICER to be translocated from the nucleus, or degraded via the proteasome, respectively. In order to further studies the proteins involved in ICER regulation mass spectrometry analysis was performed to identify potential candidates. We identified twenty eight ICER-interacting proteins in human melanoma cells, Sk-Mel-24. In this study we focus on two proteins with potential roles in ICER proteasomal degradation in response to the N-end rule for ubiquitination: the N-alpha-acetyltransferase 15 (NAA15) and the E3 ubiquitin-protein ligase UBR4. Using an HA-tag on the N- or C-terminus of ICER (

Indexed as

Cyclic AMP Response Element ModulatorProteasome Endopeptidase ComplexUbiquitin-Protein LigasesCell Line, TumorHumansProteolysisUbiquitinationCREM protein, humanCyclic AMP Response Element ModulatorProteasome Endopeptidase ComplexUbiquitin-Protein LigasesCancerICERNAA15N-End ruleUbiquitinationUBR4

Identifiers

PMID35227662
PMCPMC8930515
OpenAlexW4214689496

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.