SynthesisPulmonology
Pulmonary tuberculosis in intensive care setting, with a focus on the use of severity scores, a multinational collaborative systematic review.
Synthesis in Pulmonology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Development and validation of a primary care-accessible risk prediction model for severe pulmonary TB.IJTLD open · 2026Article
- Predictive Factors for Progression to Severe Pulmonary Tuberculosis in Patients with Concurrent HIV/AIDS and Type 2 Diabetes Mellitus: A Single-Center Retrospective Study.Infection and drug resistance · 2026Article
- Prevalence and short-term outcomes of acute complications of tuberculosis: a cross-sectional, monocentre, Italian study.BMC infectious diseases · 2025Article
- Pulmonary Tuberculosis Presenting as Severe Acute Respiratory Distress Syndrome in a Capsule Hotel Resident.Cureus · 2025Article
- Identification of Specific LncRNA Markers in Severe Tuberculosis for Early Diagnosis.Infection and drug resistance · 2025Article
- Clinical Efficacy of Continuous Renal Replacement Therapy in Patients with Pulmonary Tuberculosis Complicated with Sepsis: A Retrospective Observational Study.Infection and drug resistance · 2025Article
- Predictive Mortality of the Prognostic Nutritional Index Combined with APACHE II Score for Critically Ill Tuberculosis Patients.The American journal of tropical medicine and hygiene · 2024Article
- Article
- Antimicrobial Resistance in Sepsis Cases Due toHealthcare (Basel, Switzerland) · 2024Article
- ISCCM Position Statement on the Approach to and Management of Critically Ill Patients with Tuberculosis.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Diagnosis and management of severe pulmonary and extrapulmonary tuberculosis in critically ill patients: A mini review for clinicians.World journal of critical care medicine · 2024Review
- Development and Validation of a Risk Mortality Prediction Model for Patients with Pulmonary Tuberculosis Complicated by Severe Community-Acquired Pneumonia in the Intensive Care Unit.Infection and drug resistance · 2024Article
- Nutritional status affects immune function and exacerbates the severity of pulmonary tuberculosis.Frontiers in immunology · 2024Article
- Pulmonary tuberculosis complicated by pneumothorax, and acute respiratory distress syndrome (ARDS) in the settings of advanced HIV disease: A case report.Journal of clinical tuberculosis and other mycobacterial diseases · 2023Article
- Tuberculosis in Spain: An opinion paper.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023Review
- Clinical standards for drug-susceptible pulmonary TB.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022Article
- Non-Coding RNAs in Tuberculosis Epidemiology: Platforms and Approaches for Investigating the Genome's Dark Matter.International journal of molecular sciences · 2022Review
- Diagnosis and ECMO Treatment of a Critically Ill Patient With DisseminatedFrontiers in public health · 2022Article
- Tuberculosis parenteral therapeutic regimens for critical patients or non-functional intestinal tract: Brief review and proposal of protocol.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesReview
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimTuberculosis (TB) is associated with a high mortality in the intensive care unit (ICU), especially in subjects with Acute Respiratory Distress Syndrome (ARDS) requiring mechanical ventilation. Despite its global burden on morbidity and mortality, TB is an uncommon cause of ICU admission, however mortality is disproportionate to the advances in diagnosis and treatment made. Herein we report a systematic review of published studies.
methodsOur Literature search was conducted to identify studies on outcomes of individuals with TB admitted to ICU. We report and review in-hospital mortality, predictors of poorer outcomes, usefulness of severity scoring systems and potential benefits of intravenous antibiotics. Searches from Pubmed, Embase, Cochrane and Medline were conducted from inception to March 2020. Only literature in English was included.
resultsOut of 529 potentially relevant articles, 17 were included. Mortality across all studies ranged from 29-95% with an average of 52.9%. All severity scores underestimated average mortality. The most common indication for ICU admission was acute respiratory failure (36.3%). Negative predictors of outcome included hospital acquired infections, need of mechanical ventilation and vasopressors, delay in initiation of anti-TB treatment, more than one organ failure and a higher severity score. Low income, high incidence countries showed a 23.4% higher mortality rate compared to high income, low TB incidence countries.
conclusionMortality in individuals with TB admitted to ICU is high. Earlier detection and treatment initiation is needed.
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