Evidence map›Paper›PMID 35227616›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2022

Cognitive Frailty is Associated With Elevated Proinflammatory Markers and a Higher Risk of Mortality.

Breno S Diniz, Maria Fernanda Lima-Costa, Sérgio Viana Peixoto, Joselia O A Firmo, Karen C L Torres, Olindo Assis Martins-Filho, Andréa Teixeira-Carvalho, James Grady, George A Kuchel, Erico Castro-Costa

Abstract read
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In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  12. Association of Cognitive Frailty With Subsequent All-Cause Mortality Among Middle-Aged and Older Adults in 17 Countries.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025
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  16. Geroscience-Centric Perspective for Geriatric Psychiatry: Integrating Aging Biology With Geriatric Mental Health Research.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Breno S DinizUConn Center on Aging (BSD, GAK), University of Connecticut Health Center, Farmington, CT; Department of Psychiatry, School of Medicine (BSD), University of Connecticut Health Center, Farmington, CT. Electronic address: diniz@uchc.edu.
Maria Fernanda Lima-CostaCenter for Studies in Public Health and Aging (NESPE) (MFLC, SVP, JOAF, ECC), Rene Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil.
Sérgio Viana PeixotoCenter for Studies in Public Health and Aging (NESPE) (MFLC, SVP, JOAF, ECC), Rene Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil; Nursing School (SVP), Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Joselia O A FirmoCenter for Studies in Public Health and Aging (NESPE) (MFLC, SVP, JOAF, ECC), Rene Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil.
Karen C L TorresIntegrated Research Group on Biomarkers, Rene Rachou Research Center (KCLT, OAMF, ATC), Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil; Faculty of Medicine (KCLT), University José do Rosário Vellano, UNIFENAS, Belo Horizonte, Minas Gerais, Brazil.
Olindo Assis Martins-FilhoIntegrated Research Group on Biomarkers, Rene Rachou Research Center (KCLT, OAMF, ATC), Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil.
Andréa Teixeira-CarvalhoIntegrated Research Group on Biomarkers, Rene Rachou Research Center (KCLT, OAMF, ATC), Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil.
James GradyDepartment of Public Health Sciences, School of Medicine (JG), University of Connecticut Health Center, Farmington, CT.
George A KuchelUConn Center on Aging (BSD, GAK), University of Connecticut Health Center, Farmington, CT.
Erico Castro-CostaCenter for Studies in Public Health and Aging (NESPE) (MFLC, SVP, JOAF, ECC), Rene Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil.

Funding

Research Education ComponentP30AG067988 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Richard H Fortinsky, GEORGE A KUCHEL · 2021 to 2026
$9.5M
NIA NIH HHS P30 AG067988
6 · The paper itself

Abstract

backgroundCognitive impairment and physical frailty are common among older adults and associated with a higher likelihood of adverse health outcomes. These two conditions frequently coexist in the same individual as cognitive frailty, yet few studies have examined the impact of such comorbidity on clinical outcomes or underlying biological mechanisms.

methodsA total of 1,340 older adults (age ≥60 years old) from the Bambui Cohort Study of Ageing, with a total follow-up of 10 years, were included in this study. Frailty was defined by the accumulation of deficit framework and cognitive impairment based on scores on the MMSE less than 22. In addition, serum IL-6 levels were measured by cytometric bead array assay.

resultsIndividuals classified with cognitive frailty had significantly higher serum IL-6 levels compared to the robust, cognitively unimpaired group. Those with cognitive frailty (aOR = 1.97 [1.18-3.27] and prefrailty and cognitive impairment (aOR = 1.83 [1.24-2.69]) had the highest mortality risk over 10 years of follow-up. Higher IL-6 levels were also independently associated with a higher mortality rate (aOR = 1.37 [1.23-1.54]).

conclusionOur study shows that cognitive Frailty indicates a vulnerability state and of increasing mortality risk. Our findings also suggested that proinflammatory abnormalities can be viewed as a central phenomenon underlying common age-related problems (e.g., cognitive impairment and Frailty) and outcomes (e.g., mortality).

Indexed as

Cognitive DysfunctionFrailtyAgedCognitionCohort StudiesFrail ElderlyGeriatric AssessmentHumansInterleukin-6Interleukin-6agingCognitive frailtyIL-6inflammationmortality

Identifiers

PMID35227616
PMCPMC9177532

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.