Evidence map›Paper›PMID 35227491›Full record

Observational studyAmerican journal of surgery2022

The vexing triad of obesity, alcohol, and coagulopathy predicts the need for multiple operations in liver transplantation.

Hunter B Moore, Yanik J Bababekov, James J Pomposelli, Megan A Adams, Cara Crouch, Dor Yoeli, Rashikh A Choudhury, Tanner Ferrell, James R Burton, Elizabeth A Pomfret and 1 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in American journal of surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Hunter B MooreDepartment of Surgery, Division of Transplant Surgery, University of Colorado, USA. Electronic address: hunter.moore@cuanschutz.edu.
Yanik J BababekovDepartment of Surgery, Division of Transplant Surgery, University of Colorado, USA.
James J PomposelliDepartment of Surgery, Division of Transplant Surgery, University of Colorado, USA.
Megan A AdamsDepartment of Surgery, Division of Transplant Surgery, University of Colorado, USA; Department of Surgery, Division of Transplant Surgery, Children's Hospital Colorado, USA.
Cara CrouchDepartment of Anesthesia, University of Colorado, USA.
Dor YoeliDepartment of Surgery, Division of Transplant Surgery, University of Colorado, USA.
Rashikh A ChoudhuryDepartment of Surgery, Division of Transplant Surgery, University of Colorado, USA.
Tanner FerrellDepartment of Surgery, Division of Transplant Surgery, University of Colorado, USA.
James R BurtonDepartment of Medicine, Division of Transplant Hepatology, University of Colorado, USA.
Elizabeth A PomfretDepartment of Surgery, Division of Transplant Surgery, University of Colorado, USA.
Trevor L NydamDepartment of Surgery, Division of Transplant Surgery, University of Colorado, USA.
University of Colorado Boulder · US

Funding

Fibrinolysis Dysfunction Impact on Graft Function in Liver TransplantationR00HL151887 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MOORE, HUNTER B · 2021 to 2023
$747k
Persistent Microvasculature Thrombosis Caused by Fibrinolysis Shutdown Driving Delayed Graft Function in Liver Transplant RecipientsK99HL151887 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MOORE, HUNTER B · 2020 to 2021
$257k
NHLBI NIH HHS K99 HL151887NHLBI NIH HHS R00 HL151887
6 · The paper itself

Abstract

introductionOne in four liver transplants (LT) require return to the operating room(R-OR) within 48 h of surgery. We hypothesize that donor, recipient, and intraoperative factors will predict R-OR.

methodsLT recipients were enrolled in an observational study to measure coagulation with thrombelastography (TEG) were assessed with transplant recipient and donor variables for risk of R-OR.

results160 recipients with a median age of 55 years and a MELD-Na of 22 were analyzed. R-OR occurred in 22%. Recipient BMI (p = 0.006), donor heavy alcohol use (p = 0.017), TEG MA (p = 0.013) during the anhepatic phase of surgery, TEG MA at anhepatic and 30-min after reperfusion (p < 0.05), and red blood cell transfusions (p < 0.001) were associated with R-OR.

conclusionThe vexing triad of recipient obesity, heavy donor alcohol use, and low TEG MA were associated with a high rate of R-OR. Strategies to reduce this sub-optimal combination of risk factors could reduce the frequency of unplanned re-operations.

Indexed as

Blood Coagulation DisordersLiver TransplantationBlood CoagulationHumansMiddle AgedObesityThrombelastographyCoagulopathyDamage control surgeryHeavy alcohol useLiver transplantationObesity

Identifiers

PMID35227491
PMCPMC9580479
OpenAlexW4213010125

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.