Evidence map›Paper›PMID 35227296›Full record

ArticleJournal of ovarian research2022

Identification of key genes associated with polycystic ovary syndrome (PCOS) and ovarian cancer using an integrated bioinformatics analysis.

Juan Zou, Yukun Li, Nianchun Liao, Jue Liu, Qunfeng Zhang, Min Luo, Jiao Xiao, Yanhua Chen, Mengjie Wang, Kexin Chen and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

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  18. CAP superfamily proteins in human: a new target for cancer therapy.Medical oncology (Northwood, London, England) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Juan Zou *Department of Obstetrics and Gynecology, The Second Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Yukun Li *Department of Obstetrics and Gynecology, The Second Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Nianchun Liao *Department of Obstetrics and Gynecology, The Second Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Jue LiuDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Qunfeng ZhangDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Min LuoClinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, Hunan, 421001, People's Republic of China.
Jiao XiaoDepartment of Endocrinology, The Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China.
Yanhua ChenInstitute of Basic Medical Sciences, College of Basic Medicine, Guilin Medical University, Guilin, Guangxi, China.
Mengjie WangDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Kexin ChenDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Juan ZengDepartment of Anesthesiology, The Second Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China. 1076006678@qq.com.
Zhongcheng MoInstitute of Basic Medical Sciences, College of Basic Medicine, Guilin Medical University, Guilin, Guangxi, China. zhchmo@hotmail.com.
University of South China · CNGuilin Medical University · CN

Funding

The present study was supported by the Hunan Provincial Health Commission 2019 Annual Scientific Research. C2019098
6 · The paper itself

Abstract

backgroundAccumulating evidence suggests a strong association between polycystic ovary syndrome (PCOS) and ovarian cancer (OC), but the potential molecular mechanism remains unclear. In this study, we identified previously unrecognized genes that are significantly correlated with PCOS and OC via bioinformatics. MATERIALS AND

methodsMultiple bioinformatic analyses, such as differential expression analysis, univariate Cox analysis, functional and pathway enrichment analysis, protein-protein interaction (PPI) network construction, survival analysis, and immune infiltration analysis, were utilized. We further evaluated the effect of OGN on FSHR expression via immunofluorescence.

resultsTCGA-OC, GSE140082 (for OC) and GSE34526 (for PCOS) datasets were downloaded. Twelve genes, including RNF144B, LPAR3, CRISPLD2, JCHAIN, OR7E14P, IL27RA, PTPRD, STAT1, NR4A1, OGN, GALNT6 and CXCL11, were identified as signature genes. Drug sensitivity analysis showed that OGN might represent a hub gene in the progression of PCOS and OC. Experimental analysis found that OGN could increase FSHR expression, indicating that OGN could regulate the hormonal response in PCOS and OC. Furthermore, correlation analysis indicated that OGN function might be closely related to m6A and ferroptosis.

conclusionsOur study identified a 12-gene signature that might be involved in the prognostic significance of OC. Furthermore, the hub gene OGN represent a significant gene involved in OC and PCOS progression by regulating the hormonal response.

Indexed as

Intercellular Signaling Peptides and ProteinsOvarian NeoplasmsPolycystic Ovary SyndromeCell Adhesion MoleculesCell Line, TumorChemokine CXCL11Computational BiologyDendritic CellsDisease ProgressionDrug Resistance, NeoplasmFemaleFerroptosisHumansImmunoglobulin J-ChainsInterferon Regulatory FactorsMembrane GlycoproteinsCell Adhesion MoleculesChemokine CXCL11CRISPLD2 protein, humanCXCL11 protein, humanFSHR protein, humanGPM6A protein, humanIL27RA protein, humanImmunoglobulin J-ChainsIntercellular Signaling Peptides and ProteinsInterferon Regulatory FactorsJCHAIN protein, humanLPAR3 protein, humanMembrane GlycoproteinsN-AcetylgalactosaminyltransferasesNerve Tissue ProteinsNR4A1 protein, humanNuclear Receptor Subfamily 4, Group A, Member 1OGN protein, humanPolypeptide N-acetylgalactosaminyltransferasePTPRD protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 2Receptors, FSHReceptors, InterleukinReceptors, Lysophosphatidic AcidRNA, MessengerRNF144B protein, humanSTAT1 protein, humanSTAT1 Transcription FactorUbiquitin-Protein LigasesBioinformatic analysisOGNOvarian cancerPolycystic ovary syndromePrognostic marker

Identifiers

PMID35227296
PMCPMC8886837
OpenAlexW4220885264

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.