Evidence map›Paper›PMID 35227201›Full record

ArticleBMC geriatrics2022

Computed tomography findings and prognosis in older COVID-19 patients.

Chukwuma Okoye, Panaiotis Finamore, Giuseppe Bellelli, Alessandra Coin, Susanna Del Signore, Stefano Fumagalli, Pietro Gareri, Alba Malara, Enrico Mossello, Caterina Trevisan and 4 more

Registry-linked trialOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04379440 (Geriatric Population COVID-19 Syndromic Characteristics and Clinical Outcomes), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04379440 unknown statusnot on this map

Geriatric Population COVID-19 Syndromic Characteristics and Clinical Outcomes: a Multi-setting, Multi-domain Observational Study (GEROCOVID Observational)

Typeobservational_patient_registrySponsorRaffaele Antonelli IncalziRan2020 to 2020Enrolled1,500ConditionsCOVID-19
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Observational
  2. Observational
  3. Article
  4. Article
  5. Epidemiology and Clinical Presentation of COVID-19 in Older Adults.Infectious disease clinics of North America · 2023
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Chukwuma OkoyeGeriatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Panaiotis FinamoreGeriatrics Unit, Department of Medicine, Campus Bio-Medico University and Teaching Hospital, Rome, Italy. p.finamore@unicampus.it.
Giuseppe BellelliSchool of Medicine and Surgery, Acute Geriatric Unit, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy.
Alessandra CoinGeriatrics Unit and the GeroCovid Working Group, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Susanna Del SignoreBluecompanion Ltd, London, UK, England.
Stefano FumagalliGeriatric Intensive Care Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Pietro GareriCenter for Cognitive Disorders and Dementia - Catanzaro Lido, ASP Catanzaro, Italy.
Alba MalaraANASTE Humanitas Foundation, Rome, Italy.
Enrico MosselloGeriatric Intensive Care Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Caterina TrevisanGeriatrics Unit and the GeroCovid Working Group, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Stefano VolpatoDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Gianluca ZiaBluecompanion Ltd, London, UK, England.
Fabio MonzaniGeriatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Raffaele Antonelli IncalziGeriatrics Unit, Department of Medicine, Campus Bio-Medico University and Teaching Hospital, Rome, Italy.
Università Campus Bio-Medico · ITUniversity of Florence · ITUniversity of Padua · ITUniversity of Pisa · ITHumanitas University · ITUniversity of Ferrara · ITUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn older and multimorbid patients, chronic conditions may affect the prognostic validity of computed tomography (CT) findings in COVID-19. This study aims at assessing to which extent CT findings have prognostic implications in COVID-19 older patients.

methodsHospitalized COVID-19 patients aged 60 years or more enrolled in the multicenter, observational and longitudinal GeroCovid study who underwent chest CT were included. Patients were stratified by tertiles of age and pneumonia severity to compare CT findings. Hierarchical clustering based on CT findings was performed to identify CT-related classificatory constructs, if any. The hazard ratio (HR) of mortality was calculated for individual CT findings and for clusters, after adjusting for potential confounders.

results380 hospitalized COVID-19 patients, with a mean age of 78 (SD:9) years, underwent chest CT scan. Ground glass opacity (GGO), consolidation, and pleural effusion were the three most common CT findings, with GGO prevalence decreasing from younger to older patients and pleural effusion increasing. More severe the pneumonia more prevalent were GGO, consolidation and pleural effusion. HR of mortality was 1.94 (95%CI 1.24-3.06) for pleural effusion and 13 (95%CI 6.41-27) for cluster with a low prevalence of GGO and a high prevalence of pleural effusion ("LH"), respectively. Out of the three CT based clusters, "LH" was the only independent predictor in the multivariable model.

conclusionsPleural effusion qualifies as a distinctive prognostic marker in older COVID-19 patients. Research is needed to verify whether pleural effusion reflects COVID-19 severity or a coexisting chronic condition making the patient at special risk of death.

trial registrationClinicalTrials.gov: NCT04379440.

Indexed as

COVID-19AgedHumansLungPrognosisRetrospective StudiesSARS-CoV-2Tomography, X-Ray ComputedOldOldestPleuralSARS-CoV-2TomographyX-ray computed

Identifiers

PMID35227201
PMCPMC8885320
OpenAlexW4214777386

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.