ArticleBMC emergency medicine2022
The association between continuous renal replacement therapy as treatment for sepsis-associated acute kidney injury and trend of lactate trajectory as risk factor of 28-day mortality in intensive care units.
Article in BMC emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Diminished plasma levels of GPIb-Frontiers in medicine · 2026Trial
- Lactate in acute kidney injury: pathobiology, risk stratification, and clinical interpretation.Renal failure · 2026Review
- Sepsis-Associated Acute Kidney Injury and 28-Day Mortality in Critically Ill Patients with Sepsis: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Blood biomarker trajectories in ICU-directed prediction models - A scoping review.The EPMA journal · 2026Review
- Trajectory models of serum creatinine and 28-day mortality in critically ill patients with sepsis complicated by type 2 diabetes mellitus: a cohort study.Frontiers in endocrinology · 2026Article
- Peak Lactate Within 24 h and Mortality in Septic Shock Patients Receiving Continuous Renal Replacement Therapy: A Real-World Cohort from an Asian ICU (2018-2020).Life (Basel, Switzerland) · 2025Article
- Lactate to hemoglobin ratio predicts short and long term mortality in critically ill patients with Gastrointestinal bleeding.Scientific reports · 2025Article
- Efficacy and prognostic analysis of the oXiris® filter in sepsis-associated acute kidney injury.International urology and nephrology · 2025Article
- Development and validation of a predictive model for continuous renal replacement therapy in sepsis patients using the MIMIC-IV database.Scientific reports · 2025Article
- Large Language Model-Driven Knowledge Graph Construction in Sepsis Care Using Multicenter Clinical Databases: Development and Usability Study.Journal of medical Internet research · 2025Article
- Association between serum anion gap trajectory and mortality in hospitalized patients with sepsis: an analysis of the MIMIC-IV database.Frontiers in endocrinology · 2025Article
- Effects of closed- versus open-system intensive care units on mortality rates in patients with cancer requiring emergent surgical intervention for acute abdominal complications: a single-center retrospective study in Korea.Acute and critical care · 2024Article
- Lactate Profile Assessment-A Good Predictor of Prognosis in Patients with COVID-19 and Septic Shock Requiring Continuous Renal Therapy.Clinics and practice · 2024Article
- Post-translational modifications in sepsis-induced organ dysfunction: mechanisms and implications.Frontiers in immunology · 2024Review
- Plasma neutrophil extracellular traps in patients with sepsis-induced acute kidney injury serve as a new biomarker to predict 28-day survival outcomes of disease.Frontiers in medicine · 2024Article
- Role of serum lactate as prognostic marker of mortality among emergency department patients with multiple conditions: A systematic review.SAGE open medicine · 2023Review
- Ceftazidime/Avibactam-Based Versus Polymyxin B-Based Therapeutic Regimens for the Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infection in Critically Ill Patients: A Retrospective Cohort Study.Infectious diseases and therapy · 2022Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis has high incidence and fatality rates in intensive care units, often leading to renal failure. The effectiveness of continuous renal replacement therapy (CRRT) in sepsis-associated acute kidney injury (S-AKI) patients is currently uncertain.
aimJoint model was used to determine the association between CRRT and the lactate trajectory trend and how it correlated to 28-day mortality for S-AKI patient in ICU.
methodsA retrospective study was applied to patients with sepsis and AKI, which were extracted from the MIMIC-III public database, with the endpoint being 28-day mortality. Every lactate level measurement within 28 days was observed and calculated using logarithms. Joint model combined the longitudinal analysis of the natural logarithm of the lactate level [log(lactate)] in longitudinal submodel and Cox regression by trajectory function, demonstrating the effects of CRRT on 28-day survival and log(lactate) changes, and its final relationship with the event status.
resultsAmong the 717 S-AKI patients, 157 received CRRT. CRRT was not associated with 28-day mortality. After adjustments, the relationship between CRRT use and log(lactate) elevation was statistically significant. The parameter estimation of CRRT and log(lactate) indicated that using CRRT will increase log(lactate) by 0.041 in S-AKI patients. The joint model also instigated a fixed association between changes in the lactate level and the event result, revealing an exp value of (0.755) = 2.12, indicating that an increase of one unit in log(lactate) will increase the risk of 28-day mortality 2.12-times.
conclusionThere was no significant association between CRRT use and 28-day survival in S-AKI patients, and JM showed that CRRT use might be associated with elevation of longitudinal lactate levels. Therefore, additional attention should be paid to other treatments to control lactate levels when providing renal support for patients with S-AKI.
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