Evidence map›Paper›PMID 35227071›Full record

ArticlemBio2022

Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model.

Sebastian Suerbaum, Nina Coombs, Lubna Patel, Dimitri Pscheniza, Katharina Rox, Christine Falk, Achim D Gruber, Olivia Kershaw, Patrick Chhatwal, Mark Brönstrup and 2 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. New Directions inInfection and drug resistance · 2025
    Review
  5. Opportunities forMicroorganisms · 2024
    Review
  6. Antibiotics (Basel, Switzerland) · 2024
    Review
  7. Review
  8. Helicobacter pylori infection.Nature reviews. Disease primers · 2023
    Review
  9. Frontiers in cellular and infection microbiology · 2023
    Review
  10. Anti-Frontiers in microbiology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Sebastian Suerbaum *Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical Schoolgrid.10423.34, Hannover, Germany.
Nina CoombsInstitute for Medical Microbiology and Hospital Epidemiology, Hannover Medical Schoolgrid.10423.34, Hannover, Germany.
Lubna PatelMax von Pettenkofer Institute for Hygiene and Medical Microbiology, Munich, Germany.
Dimitri PschenizaInstitute for Medical Microbiology and Hospital Epidemiology, Hannover Medical Schoolgrid.10423.34, Hannover, Germany.
Katharina RoxDepartment of Chemical Biology, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.
Christine FalkInstitute of Transplant Immunology, Hannover Medical Schoolgrid.10423.34, Hannover, Germany.
Achim D GruberInstitute of Veterinary Pathology, Free University Berlin, Berlin, Germany.
Olivia KershawInstitute of Veterinary Pathology, Free University Berlin, Berlin, Germany.
Patrick ChhatwalInstitute for Medical Microbiology and Hospital Epidemiology, Hannover Medical Schoolgrid.10423.34, Hannover, Germany.
Mark BrönstrupDepartment of Chemical Biology, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.ORCID 0000-0002-8971-7045
Ursula BilitewskiDepartment of Chemical Biology, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.
Christine Josenhans *Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical Schoolgrid.10423.34, Hannover, Germany.
Medizinische Hochschule Hannover · DEGerman Center for Infection Research · DEFreie Universität Berlin · DEInstitute of Medical Microbiology and Hygiene · DE

Funding

Deutsches Zentrum für Infektionsforschung (DZIF) 06.801Deutsches Zentrum für Infektionsforschung (DZIF) 06.804Deutsches Zentrum für Infektionsforschung (DZIF) 09.713
6 · The paper itself

Abstract

New treatment options against the widespread cancerogenic gastric pathogen Helicobacter pylori are urgently needed. We describe a novel screening procedure for inhibitors of H. pylori flagellar biosynthesis. The assay is based on a

Indexed as

Helicobacter InfectionsHelicobacter pyloriAnimalsAnti-Bacterial AgentsBacterial ProteinsDisease Models, AnimalFlagellaFlagellinHumansMiceStomachAnti-Bacterial AgentsBacterial ProteinsFlagellindrug screeningflagellar motilityHelicobacter pylorimotility inhibitor

Identifiers

PMID35227071
PMCPMC8941896
OpenAlexW4214656881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.