Evidence map›Paper›PMID 35227037›Full record

ArticleTurkish journal of pharmaceutical sciences2022

Influence of Vehicles and Penetration Enhancers on the Permeation of Cinnarizine Through the Skin

Şükran Damgalı, Samet Özdemir, Asli Barla Demirkoz, Melike Üner

Open access · diamondAbstract read
In one paragraph

Article in Turkish journal of pharmaceutical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Şükran DamgalıIstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul, TurkeyORCID 0000-0001-9540-2544
Samet ÖzdemirIstanbul Health and Technology University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul, TurkeyORCID 0000-0001-6212-2706
Asli Barla DemirkozAromsa Flavours and Food Additives Inc. Co., Department of Research and Development Center, Kocaeli, TurkeyORCID 0000-0002-3261-0212
Melike ÜnerIstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul, TurkeyORCID 0000-0003-2786-5947
Haliç University · TRIstanbul Health and Technology University

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The aim of this study was to determine the influence of vehicles and penetration enhancers on the penetration and permeation of cinnarizine (CNZ) through the skin. Materials and Methods: Topical formulations based on hydrogel, o/w emulsion and oleaginous cream were prepared. After determination of physical properties of formulations, the penetration and permeation of CNZ through the Results: The cumulative amount of CNZ permeated from the base hydrogel formulation was about 5 times higher than the base o/w emulsion and base oleaginous cream formulations. The incorporation of penetration enhancers to the base hydrogel and o/w emulsion formulations generally increased CNZ penetration through the skin. Transcutol Conclusion: It was concluded that the hydrogel containing Transcutol

Indexed as

CinnarizineMénière’s diseasemotion sicknesspenetration enhancersskin permeation

Identifiers

PMID35227037
PMCPMC8892562
OpenAlexW3154838210

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.