Evidence map›Paper›PMID 35226474›Full record

ArticleACS sensors2022

Ratiometric Imaging of Mitochondrial Hydrogen Peroxide in Aβ

Xinyu Li, Yiyu Zhang, Hui-Wang Ai

Open access · greenAbstract read
In one paragraph

Article in ACS sensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. The interaction between oxidative stress and Schwann cells.Experimental biology and medicine (Maywood, N.J.) · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xinyu LiDepartment of Molecular Physiology and Biological Physics, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, United States.
Yiyu ZhangDepartment of Molecular Physiology and Biological Physics, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, United States.
Hui-Wang AiDepartment of Molecular Physiology and Biological Physics, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, United States.ORCID 0000-0002-5664-3270
University of Virginia · US

Funding

Red and Far-Red Fluorescent Biosensors for Compartmentalized Redox SignalingR01GM129291 · NIGMS · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2018 to 2021
$2.1M
NIGMS NIH HHS R01 GM129291
6 · The paper itself

Abstract

Oxidative stress is important for the etiology and pathogenesis of Alzheimer's disease (AD). Research tools that can conveniently evaluate oxidative stress in AD models are expected to catalyze and accelerate research on AD. This study explored the use of genetically encoded fluorescent indicators (GEFIs) to detect mitochondrial oxidative stress in organotypic brain slices and AD mouse models. To enable ratiometric normalization and avoid tissue autofluorescence, we genetically fused a green fluorescent hydrogen peroxide (H

Indexed as

Alzheimer DiseaseHydrogen PeroxideAmyloid beta-PeptidesAnimalsDisease Models, AnimalHeLa CellsHumansMiceMitochondriaPeptide FragmentsAmyloid beta-PeptidesHydrogen PeroxidePeptide FragmentsAlzheimer’s diseasefluorescent proteinsgenetically encoded fluorescent indicatorsoxidative stressratiometric imaging

Identifiers

PMID35226474
PMCPMC8957525
OpenAlexW4214916054

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.