Evidence map›Paper›PMID 35226409›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022

Remote blood collection from older adults in the Brain Health Registry for plasma biomarker and genetic analysis.

Juliet Fockler, Miriam T Ashford, Joseph Eichenbaum, Taylor Howell, Aniekan Ekanem, Derek Flenniken, Alexander Happ, Diana Truran, R Scott Mackin, Kaj Blennow and 4 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. The ADNI Administrative Core: Ensuring ADNI's success and informing future AD clinical trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  3. Article
  4. Brain health registry updates: An online longitudinal neuroscience platform.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Juliet FocklerVA Advanced Imaging Research Center, San Francisco Veteran's Administration Medical Center, San Francisco, California, USA.
Miriam T AshfordVA Advanced Imaging Research Center, San Francisco Veteran's Administration Medical Center, San Francisco, California, USA.
Joseph EichenbaumVA Advanced Imaging Research Center, San Francisco Veteran's Administration Medical Center, San Francisco, California, USA.ORCID 0000-0003-1841-5936
Taylor HowellVA Advanced Imaging Research Center, San Francisco Veteran's Administration Medical Center, San Francisco, California, USA.
Aniekan EkanemVA Advanced Imaging Research Center, San Francisco Veteran's Administration Medical Center, San Francisco, California, USA.
Derek FlennikenVA Advanced Imaging Research Center, San Francisco Veteran's Administration Medical Center, San Francisco, California, USA.
Alexander HappVA Advanced Imaging Research Center, San Francisco Veteran's Administration Medical Center, San Francisco, California, USA.
Diana TruranVA Advanced Imaging Research Center, San Francisco Veteran's Administration Medical Center, San Francisco, California, USA.
R Scott MackinVA Advanced Imaging Research Center, San Francisco Veteran's Administration Medical Center, San Francisco, California, USA.
Kaj BlennowInstitute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden.
Eran HalperinDepartment of Computer Science, University of California, Los Angeles, Los Angeles, California, USA.
Giovanni CoppolaRegeneron Genetics Center, Tarrytown, New York, USA.
Michael W WeinerVA Advanced Imaging Research Center, San Francisco Veteran's Administration Medical Center, San Francisco, California, USA.
Rachel L NoshenyVA Advanced Imaging Research Center, San Francisco Veteran's Administration Medical Center, San Francisco, California, USA.

Funding

The Brain Health Registry for facilitating interdisciplinary aging researchR33AG062867 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOSHENY, RACHEL LAUREN · 2020 to 2024
$3.2M
Implementation and validation of an online Caregiver and Study Partner Portal for assessment of cognitive function in older adultsK01AG055692 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOSHENY, RACHEL LAUREN · 2017 to 2021
$719k
Inclusion and participation of older adults from underrepresented populations in cognitive aging and Alzheimer's disease-related researchF32AG072730 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI ASHFORD, MIRIAM · 2021 to 2023
$226k
NIA NIH HHS F32 AG072730NIA NIH HHS K01 AG055692NIA NIH HHS K01AG055692NIA NIH HHS R33 AG062867
6 · The paper itself

Abstract

introductionUse of online registries to efficiently identify older adults with cognitive decline and Alzheimer's disease (AD) is an approach with growing evidence for feasibility and validity. Linked biomarker and registry data can facilitate AD clinical research.

methodsWe collected blood for plasma biomarker and genetic analysis from older adult Brain Health Registry (BHR) participants, evaluated feasibility, and estimated associations between demographic variables and study participation.

resultsOf 7150 participants invited to the study, 864 (12%) enrolled and 629 (73%) completed remote blood draws. Participants reported high study acceptability. Those from underrepresented ethnocultural and educational groups were less likely to participate. DISCUSSION: This study demonstrates the challenges of remote blood collection from a large representative sample of older adults. Remote blood collection from > 600 participants within a short timeframe demonstrates the feasibility of our approach, which can be expanded for efficient collection of plasma AD biomarker and genetic data.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedBiomarkersBrainHumansRegistriesBiomarkersacceptabilityaging researchAlzheimer's diseasebrain health registryeducationengagementethnicityfeasibilitygeneticsinternetplasma biomarkersraceresearch registry

Identifiers

PMID35226409
PMCPMC9998146

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.