ArticleAnnals of neurology2022
Distinct Roles of Rodent Thalamus and Corpus Callosum in Seizure Generalization.
Article in Annals of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 22 citations in OpenAlex.
- Bilateral detection, prediction, and lateralization of seizures using white matter.Epilepsia open · 2026Article
- A Dispersive Image Scanning Microscope for Multi-color High-resolution Imaging.ACS photonics · 2026Article
- Thrombin mediates seizures following cortical injury-induced status epilepticus.Epilepsy research · 2025Article
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- Seizure network characterization by functional connectivity mapping and manipulation.Neurophotonics · 2025Article
- Alterations in White Matter Structure in Sleep-Related Epilepsies: A TBSS-Based Diffusion Tensor Imaging Study.Neuropsychiatric disease and treatment · 2025Article
- Impact of anterior callosal disconnection on picture naming in frontal lobe epilepsy surgery.Brain communications · 2025Article
- Mesoscopic mapping of hemodynamic responses and neuronal activity during pharmacologically induced interictal spikes in awake and anesthetized mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Article
- Quantitative MRI reveals widespread, network-specific myelination change during generalized epilepsy progression.NeuroImage · 2023Article
- Characteristics of ictal thalamic EEG in pediatric-onset neocortical focal epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Characteristics of ictal thalamic EEG in pediatric-onset neocortical focal epilepsy.medRxiv : the preprint server for health sciences · 2023Article
- Deep learning distinguishes connectomes from focal epilepsy patients and controls: feasibility and clinical implications.Brain communications · 2023Article
- Focal Seizures Cruise the Callosal Highway.Epilepsy currentsArticle
- Assessing oligodendrocyte and myelin alterations following absence seizures in a rat model ofBrain and neuroscience advancesArticle
- Connectivity and Excitability Shape Seizure Circuits.Epilepsy currentsReview
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5 authors at 2 institutions in 1 country.
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Abstract
objectiveBilateral synchronous cortical activity occurs during sleep, attention, and seizures. Canonical models place the thalamus at the center of bilateral cortical synchronization because it generates bilateral sleep spindle oscillations and primarily generalized absence seizures. However, classical studies suggest that the corpus callosum mediates bilateral cortical synchronization.
methodsWe mapped the spread of right frontal lobe-onset, focal to bilateral seizures in mice and modified it using chemo and optogenetic suppression of motor thalamic nucleus and corpus callosotomy.
resultsSeizures from the right cortex spread faster to the left cortex than to the left thalamus. The 2 thalami have minimal monosynaptic commissural connections compared to the massive commissure corpus callosum. Chemogenetic and closed-loop optogenetic inhibition of the right ventrolateral thalamic nucleus did not alter inter-hemispheric seizure spread. However, anterior callosotomy delayed bilateral seizure oscillations.
interpretationThalamocortical oscillations amplify focal onset motor seizures, and corpus callosum spreads them bilaterally. ANN NEUROL 2022;91:682-696.
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