Evidence map›Paper›PMID 35226307›Full record

ArticleUpdates in surgery2022

Current practice of normothermic regional perfusion and machine perfusion in donation after circulatory death liver transplants in Italy.

Riccardo De Carlis, Andrea Lauterio, Leonardo Centonze, Vincenzo Buscemi, Andrea Schlegel, Paolo Muiesan, Luciano De Carlis, Italian DCD Collaborator Group

Abstract read
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In one paragraph

Article in Updates in surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  11. Hyperspectral Imaging as a Tool for Viability Assessment During Normothermic Machine Perfusion of Human Livers: A Proof of Concept Pilot Study.Transplant international : official journal of the European Society for Organ Transplantation · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Riccardo De CarlisDepartment of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162, Milan, Italy. riccardo.decarlis@ospedaleniguarda.it.ORCID http://orcid.org/0000-0003-3697-1653
Andrea LauterioDepartment of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.ORCID http://orcid.org/0000-0001-6110-8582
Leonardo CentonzeDepartment of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.ORCID http://orcid.org/0000-0001-9371-7411
Vincenzo BuscemiDepartment of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.ORCID http://orcid.org/0000-0002-2225-543X
Andrea SchlegelDepartment of Surgery and Transplantation, Swiss HPB Center, University Hospital Zurich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-9385-9847
Paolo MuiesanGeneral and Liver Transplant Surgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID http://orcid.org/0000-0002-7389-6691
Luciano De CarlisDepartment of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.ORCID http://orcid.org/0000-0002-9133-8220
Italian DCD Collaborator Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNormothermic regional perfusion (NRP) and machine perfusion (MP) are variously used in many European centers to improve the outcomes after liver transplantation from donation after circulatory death (DCD). In Italy, a combination of NRP and subsequent MP has been used since the start of the activity. While NRP is mandatory for every DCD recovery, the subsequent use of MP is left to each center.

methodsWe have designed a national survey to investigate practices and policies of these techniques. The questionnaire included 46 questions and was distributed to all the 21 Italian centers using an online form between June and July 2021.

resultsThe overall response rate was 100%. A local NRP program for controlled Maastricht type 3 DCD was active in 11/21 (52.4%) centers. Organization and availability of personnel were perceived as the main difficulties in starting such a program. Between 2015 and 2020, 119 DCD livers were transplanted, with an overall utilization rate of 69.2%. Pump flow and gross aspect were considered the most reliable parameters in liver selection during NRP. Eight (72.7%) centers adopted subsequent hypothermic MP, 1 (9.1%) center normothermic MP, and the remaining 2 (18.2%) used both MP types.

conclusionThis first snapshot survey shows that NRP with subsequent MP is the most used protocol in Italy for DCD livers, although some heterogeneity exists in the type and purpose of MP between centers. Overall, this policy ensures a high utilization rate, considering the high risk of the DCD donor population in Italy.

Indexed as

Liver TransplantationGraft SurvivalHumansOrgan PreservationPerfusionTissue DonorsHypothermic oxygenated perfusionIschemic-type biliary lesionsLiver preservationLiver utilizationWarm ischemia

Identifiers

PMID35226307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.