Evidence map›Paper›PMID 35226290›Full record

ArticleDrug delivery and translational research2022

Therapeutic effects of dexamethasone-loaded hyaluronan nanogels in the experimental cholestasis.

Sabina Di Matteo, Chiara Di Meo, Guido Carpino, Nicole Zoratto, Vincenzo Cardinale, Lorenzo Nevi, Diletta Overi, Daniele Costantini, Claudio Pinto, Elita Montanari and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery and translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Sabina Di MatteoDepartment of Immunology, Bambino Gesù Childrens Hospital, IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-2586-7159
Chiara Di MeoDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. chiara.dimeo@uniroma1.it.ORCID http://orcid.org/0000-0002-3531-6107
Guido CarpinoDepartment of Movement, Division of Health Sciences, Human and Health Sciences, University of Rome "Foro Italico, Rome, Italy.
Nicole ZorattoDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.
Vincenzo CardinaleDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy. vincenzo.cardinale@uniroma1.it.
Lorenzo NeviDepartment of Biosciences, University of Milan, Milan, Italy.
Diletta OveriDepartment of Anatomical, Forensic, Medicine and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy.
Daniele CostantiniDepartment of Precision and Translational Medicine, Sapienza University of Rome, Rome, Italy.
Claudio PintoDepartment of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ancona, Italy.
Elita MontanariDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.
Marco MarzioniDepartment of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ancona, Italy.
Luca MaroniDepartment of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ancona, Italy.
Antonio BenedettiDepartment of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ancona, Italy.
Marco ViolaDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.
Tommasina CovielloDepartment of Movement, Division of Health Sciences, Human and Health Sciences, University of Rome "Foro Italico, Rome, Italy.
Pietro MatricardiDepartment of Movement, Division of Health Sciences, Human and Health Sciences, University of Rome "Foro Italico, Rome, Italy.
Eugenio GaudioDepartment of Anatomical, Forensic, Medicine and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy.
Domenico AlvaroDepartment of Precision and Translational Medicine, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITMarche Polytechnic University · ITForo Italico University of Rome · ITBambino Gesù Children's Hospital · ITUniversità Campus Bio-Medico · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A major function of the intrahepatic biliary epithelium is bicarbonate excretion in bile. Recent reports indicate that budesonide, a corticosteroid with high receptor affinity and hepatic first pass clearance, increases the efficacy of ursodeoxycholic acid, a choleretic agent, in primary biliary cholangitis patients. We have previously reported that bile ducts isolated from rats treated with dexamethasone or budesonide showed an enhanced activity of the Na

Indexed as

BicarbonatesCholestasisAnimalsBudesonideDexamethasoneHyaluronic AcidMiceNanogelsRatsBicarbonatesBudesonideDexamethasoneHyaluronic AcidNanogelsCholestasisDexamethasoneHyaluronic acidNanogelsPrimary biliary cholangitis

Identifiers

PMID35226290
PMCPMC9242918
OpenAlexW4214592657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.