ArticleEuropean journal of nuclear medicine and molecular imaging2022
Image-level trajectory inference of tau pathology using variational autoencoder for Flortaucipir PET.
Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Generative AI Models in Time-Varying Biomedical Data: Scoping Review.Journal of medical Internet research · 2025Article
- Multi-modal Imaging-based Pseudotime Analysis of Alzheimer progression.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025Article
- Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms.Translational psychiatry · 2024Review
- MRI-based mild cognitive impairment and Alzheimer's disease classification using an algorithm of combination of variational autoencoder and other machine learning classifiers.Journal of Alzheimer's disease reports · 2024Article
- A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles.Brain communications · 2024Review
- Application of Deep Learning for Prediction of Alzheimer's Disease in PET/MR Imaging.Bioengineering (Basel, Switzerland) · 2023Review
- Multi-Modal Neuroimaging Neural Network-Based Feature Detection for Diagnosis of Alzheimer's Disease.Frontiers in aging neuroscience · 2022Article
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10 authors.
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Abstract
purposeAlzheimer's disease (AD) studies revealed that abnormal deposition of tau spreads in a specific spatial pattern, namely Braak stage. However, Braak staging is based on post mortem brains, each of which represents the cross section of the tau trajectory in disease progression, and numerous studies were reported that do not conform to that model. This study thus aimed to identify the tau trajectory and quantify the tau progression in a data-driven approach with the continuous latent space learned by variational autoencoder (VAE).
methodsA total of 1080 [
resultsWe identified four clusters that plausibly capture certain stages of AD and organized the clusters in the latent space. The inferred tau trajectory agreed with the Braak staging. According to the derived pseudo-time, tau first deposits in the parahippocampal and amygdala, and then spreads to the fusiform, inferior temporal lobe, and posterior cingulate. Prior to the regional tau deposition, amyloid accumulates first.
conclusionThe spatiotemporal trajectory of tau progression inferred in this study was consistent with Braak staging. The profile of other biomarkers in disease progression agreed well with previous findings. We addressed that this approach additionally has the potential to quantify tau progression as a continuous variable by taking a whole-brain tau image into account.
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