ArticleJournal of functional biomaterials2022
Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration.
Article in Journal of functional biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Nanohydroxyapatite and its composite scaffold for bone tissue engineering application: a systematic review.Journal of materials science. Materials in medicine · 2025Pooled it
- Aligned PLGA/nHA fiber scaffolds for enhancing osteogenic differentiation of human periodontal ligament stem cells.Frontiers in bioengineering and biotechnology · 2026Article
- Microstructural characterization and osteogenic efficacy of PVA/PVP blended mineral scaffold for bone tissue engineering.Journal of materials science. Materials in medicine · 2025Article
- A Systematic Review of Metal Composite Bone Grafts in Preclinical Spinal Fusion Models.Biomimetics (Basel, Switzerland) · 2025Review
- Fabrication of biodegradable nanocomposite scaffolds with hydroxyapatite, magnetic clay, and graphene oxide for bone tissue engineering.Scientific reports · 2025Article
- Fabrication and Characterization of Electrospun Sr/Zn-Doped Nano-Hydroxyapatite-Collagen-PLGA Nanofibrous Scaffolds for Bone Tissue Engineering.International journal of nanomedicine · 2025Article
- Zinc Doped Synthetic Polymer Composites for Bone Regeneration: A Promising Strategy to Repair Bone Defects.International journal of nanomedicine · 2025Review
- Cellular Senescence and Inflammaging in the Bone: Pathways, Genetics, Anti-Aging Strategies and Interventions.International journal of molecular sciences · 2024Review
- Article
- Harnessing the Potential of PLGA Nanoparticles for Enhanced Bone Regeneration.Pharmaceutics · 2024Review
- Towards the Clinical Translation of 3D PLGA/β-TCP/Mg Composite Scaffold for Cranial Bone Regeneration.Materials (Basel, Switzerland) · 2024Article
- Metal Ion-Doped Hydroxyapatite-Based Materials for Bone Defect Restoration.Bioengineering (Basel, Switzerland) · 2023Review
- Advances in Biodegradable Polymers and Biomaterials for Medical Applications-A Review.Molecules (Basel, Switzerland) · 2023Review
- Article
- Article
- Enhanced In Vitro Biocompatible Polycaprolactone/Nano-Hydroxyapatite Scaffolds with Near-Field Direct-Writing Melt Electrospinning Technology.Journal of functional biomaterials · 2022Article
- Bioactive Composite for Orbital Floor Repair and Regeneration.International journal of molecular sciences · 2022Article
- Physical and Chemical Characterization of Biomineralized Collagen with Different Microstructures.Journal of functional biomaterials · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
Abstract
Synthetic bone graft substitutes have attracted increasing attention in tissue engineering. This study aimed to fabricate a novel, bioactive, porous scaffold that can be used as a bone substitute. Strontium and zinc doped nano-hydroxyapatite (Sr/Zn n-HAp) were synthesized by a water-based sol-gel technique. Sr/Zn n-HAp and poly (lactide-co-glycolide) (PLGA) were used to fabricate composite scaffolds by supercritical carbon dioxide technique. FTIR, XRD, TEM, SEM, and TGA were used to characterize Sr/Zn n-HAp and the composite scaffolds. The synthesized scaffolds were adequately porous with an average pore size range between 189 to 406 µm. The scaffolds demonstrated bioactive behavior by forming crystals when immersed in the simulated body fluid. The scaffolds after immersing in Tris/HCl buffer increased the pH value of the medium, establishing their favorable biodegradable behavior. ICP-MS study for the scaffolds detected the presence of Sr, Ca, and Zn ions in the SBF within the first week, which would augment osseointegration if implanted in the body. nHAp and their composites (PLGA-nHAp) showed ultimate compressive strength ranging between 0.4-19.8 MPa. A 2.5% Sr/Zn substituted nHAp-PLGA composite showed a compressive behavior resembling that of cancellous bone indicating it as a good candidate for cancellous bone substitute.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.