ReviewJournal of developmental biology2022
Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy.
Review in Journal of developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- A single-center retrospective study of a decade-long experience in managing pediatric lymphatic malformation.BMC pediatrics · 2026Article
- An Imaging-Based LIE Classification for Risk Stratification of Resectability in Pediatric Abdominal Lymphatic Malformations.Children (Basel, Switzerland) · 2026Article
- Uncommon Presentation of a Macrocystic Lymphatic Malformation in a Seven-Year-Old Boy: A Case Report.Cureus · 2026Article
- Commentary: Endoscopy-assisted surgical management for a giant axillary cystic lymphangioma: a case report.Frontiers in surgery · 2026Article
- Terminological precision in vascular anomalies: beyond "lymphangioma" and "haemangioma".Polish journal of radiology · 2026Article
- Retrospective evaluation of sirolimus (mTOR blocker) for lymphatic malformations presenting in the neonatal period: a single-center experience.Frontiers in pediatrics · 2026Article
- Diagnostic challenges and perioperative management of a lateral cystic neck mass in an adult patient with hemophilia B: A case report.SAGE open medical case reports · 2026Article
- Molecular targeted treatment in infants with central conducting lymphatic anomalies.European journal of pediatrics · 2025Article
- Zebrafish Models of Induced Lymphangiogenesis: Current Advancements and Therapeutic Discovery.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Endoscopy-assisted surgical management for a giant axillary cystic lymphangioma: a case report.Frontiers in surgery · 2025Article
- Rare Yet Relevant: Adult Onset Cervical Lymphangioma - Our Experience and Comprehensive Review.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- A multi-step approach to overcome challenges in the management of head and neck lymphatic malformations, and response to treatment.Orphanet journal of rare diseases · 2024Article
- Congenital Vascular and Lymphatic Diseases.Circulation research · 2024Review
- Percutaneous injection of sclerosant agents as an effective treatment for cystic malformations of the head and neck.Oral and maxillofacial surgery · 2024Article
- A Review of the Current State and Future Directions for Management of Scalp and Facial Vascular Malformations.Journal of Korean Neurosurgical Society · 2024Article
- Article
- Sudden Appearance of a Palpable Chest Wall Mass Secondary to Macrocystic Lymphatic Malformation: A Case Report.Children (Basel, Switzerland) · 2023Article
- The Genetic Architecture of Vascular Anomalies: Current Data and Future Therapeutic Perspectives Correlated with Molecular Mechanisms.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Lymphatic malformations are fluid-filled congenital defects of lymphatic channels occurring in 1 in 6000 to 16,000 patients. There are various types, and they often exist in conjunction with other congenital anomalies and vascular malformations. Great strides have been made in understanding these malformations in recent years. This review summarize known molecular and embryological precursors for lymphangiogenesis. Gene mutations and dysregulations implicated in pathogenesis of lymphatic malformations are discussed. Finally, we touch on current and developing therapies with special attention on targeted biotherapeutics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.