Evidence map›Paper›PMID 35225375›Full record

ArticleMagnetic resonance in medicine2022

Interleaved fluid-attenuated inversion recovery (FLAIR) MRI and deuterium metabolic imaging (DMI) on human brain in vivo.

Yanning Liu, Henk M De Feyter, Robert K Fulbright, Scott McIntyre, Terence W Nixon, Robin A de Graaf

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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  9. Parallel detection of MRI andMagnetic resonance in medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yanning LiuBiomedical Engineering, Yale University, New Haven, Connecticut, USA.ORCID 0000-0002-7861-9853
Henk M De FeyterDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.ORCID 0000-0001-6111-0316
Robert K FulbrightDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
Scott McIntyreDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
Terence W NixonDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
Robin A de GraafBiomedical Engineering, Yale University, New Haven, Connecticut, USA.ORCID 0000-0002-6570-7010
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Deuterium metabolic imaging (DMI) of neurological diseaseR01EB025840 · NIBIB · YALE UNIVERSITY · PI ROBIN A DE GRAAF, Henk De Feyter · 2019 to 2026
$4.2M
NCATS NIH HHS UL1 TR001863NIBIB NIH HHS R01 EB025840
6 · The paper itself

Abstract

purposeTo integrate deuterium metabolic imaging (DMI) with clinical MRI through an interleaved MRI and DMI acquisition workflow. Interleaved MRI-DMI was enabled with hardware and pulse sequence modifications, and the performance was demonstrated using fluid-attenuated inversion recovery (FLAIR) MRI as an example.

methodsInterleaved FLAIR-DMI was developed by interleaving the

resultsThe interleaved MRI-DMI acquisition strategy allowed simultaneous detection of FLAIR MRI and DMI in the same scan time as a FLAIR-only MRI acquisition. Both phantom and in vivo data showed that the MR image quality, DMI sensitivity as well as information content were preserved using interleaved MRI-DMI.

conclusionThe interleaved MRI-DMI technology can be used to extend clinical MRI protocols with DMI, thereby offering a metabolic component to the MR imaging contrasts without a penalty on patient comfort or scan time.

Indexed as

BrainMagnetic Resonance ImagingContrast MediaDeuteriumHumansPhantoms, ImagingContrast MediaDeuteriumdeuterium metabolic imaging (DMI)fluid-attenuated inversion recovery (FLAIR)human braininterleaved acquisition

Identifiers

PMID35225375
PMCPMC9924309
OpenAlexW4214594666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.