Evidence map›Paper›PMID 35225329›Full record

ArticleAmerican journal of epidemiology2024

Estimating Subgroup Effects in Generalizability and Transportability Analyses.

Sarah E Robertson, Jon A Steingrimsson, Nina R Joyce, Elizabeth A Stuart, Issa J Dahabreh

Open access · bronzeAbstract read
In one paragraph

Article in American journal of epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Transporting: What Is It and How Do You Do It?Current epidemiology reports · 2025
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sarah E Robertson
Jon A Steingrimsson
Nina R Joyce
Elizabeth A Stuart
Issa J Dahabreh
Brown University · USHarvard University · USJohns Hopkins University · US

Funding

Methods for generalizing inferences from cluster randomized controlled trials to target populationsR01LM013616 · NLM · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI DAHABREH, ISSA J. · 2022 to 2025
$1.4M
Transporting effects using a multicenter randomized study to different target populationsR36HS028373 · AHRQ · BROWN UNIVERSITY · PI ROBERTSON, SARAH E · 2021 to 2021
$43k
AHRQ HHS R36 HS028373NLM NIH HHS R01 LM013616
6 · The paper itself

Abstract

Methods for extending-generalizing or transporting-inferences from a randomized trial to a target population involve conditioning on a large set of covariates that is sufficient for rendering the randomized and nonrandomized groups exchangeable. Yet, decision makers are often interested in examining treatment effects in subgroups of the target population defined in terms of only a few discrete covariates. Here, we propose methods for estimating subgroup-specific potential outcome means and average treatment effects in generalizability and transportability analyses, using outcome model--based (g-formula), weighting, and augmented weighting estimators. We consider estimating subgroup-specific average treatment effects in the target population and its nonrandomized subset, and we provide methods that are appropriate both for nested and non-nested trial designs. As an illustration, we apply the methods to data from the Coronary Artery Surgery Study (North America, 1975-1996) to compare the effect of surgery plus medical therapy versus medical therapy alone for chronic coronary artery disease in subgroups defined by history of myocardial infarction.

Indexed as

Myocardial InfarctionHumansNorth Americageneralizabilityheterogeneity of treatment effectssubgroup analysistransportability

Identifiers

PMID35225329
PMCPMC11484600
OpenAlexW3204650375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.