Evidence map›Paper›PMID 35225058›Full record

ArticleInternational journal of immunopathology and pharmacology

PD-L1 expression in breast invasive ductal carcinoma with incomplete pathological response to neoadjuvant chemotherapy.

Ahmad Alhesa, Heyam Awad, Sarah Bloukh, Mahmoud Al-Balas, Mohammed El-Sadoni, Duaa Qattan, Bilal Azab, Tareq Saleh

Open access · goldAbstract read
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Peripheral TNF-α and CD8Breast cancer (Dove Medical Press) · 2025
    Article
  3. Article
  4. Review
  5. Significance of CD103BMC cancer · 2023
    Article
  6. Article
  7. Tumor immune microenvironment components and the other markers can predict the efficacy of neoadjuvant chemotherapy for breast cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ahmad AlhesaDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, 54658The University of Jordan, Amman, Jordan.
Heyam AwadDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, 54658The University of Jordan, Amman, Jordan.
Sarah BloukhDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, 54658The University of Jordan, Amman, Jordan.ORCID https://orcid.org/0000-0002-2102-6133
Mahmoud Al-BalasDepartment of General and Specialized Surgery, Faculty of Medicine, 34419The Hashemite University, Zarqa, Jordan.
Mohammed El-SadoniDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, 54658The University of Jordan, Amman, Jordan.
Duaa QattanDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, 54658The University of Jordan, Amman, Jordan.
Bilal AzabDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, 54658The University of Jordan, Amman, Jordan.
Tareq SalehDepartment of Basic Medical Sciences, Faculty of Medicine, 34419The Hashemite University, Zarqa, Jordan.
University of Jordan · JOHashemite University · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the expression of programmed death-ligand 1 (PD-L1) in breast cancer in association with incomplete pathological response (PR) to neoadjuvant chemotherapy (NAC).

methodsPD-L1 expression was evaluated using immunohistochemistry in post-operative, post-NAC samples of 60 patients (

resultsIn the post-operative, post-NAC samples (

conclusionOur findings indicate that PD-L1 protein expression in infiltrating immune cells was significantly reduced in breast tumors that developed incomplete PR following the exposure to NAC.

Indexed as

B7-H1 AntigenCarcinoma, DuctalBiomarkers, TumorHumansNeoadjuvant TherapyB7-H1 AntigenBiomarkers, TumorCD274 protein, humanbreast cancerimmunohistochemistry 22C3 pharmDximmunotherapyneoadjuvant chemotherapyoverall survivalpathological responseprogrammed death-ligand 1tumor infiltrating lymphocytes

Identifiers

PMID35225058
PMCPMC8891930
OpenAlexW4214558836

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.