Evidence map›Paper›PMID 35224991›Full record

ArticleAmerican journal of physiology. Renal physiology2022

Pendrin-null mice develop severe hypokalemia following dietary Na

Truyen D Pham, Anthony J Elengickal, Jill W Verlander, Lama Al-Qusairi, Chao Chen, Delaney C Abood, Spencer A King, Johannes Loffing, Paul A Welling, Susan M Wall

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Intercalated Cell ClC-K2 Channel Contributes to Systemic ClFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  2. Role of ENaC in gender-associated differences in blood pressure.Iranian journal of basic medical sciences · 2025
    Article
  3. Pendrin: linking acid base to blood pressure.Pflugers Archiv : European journal of physiology · 2024
    Review
  4. The K-Cl cotransporter-3 in the mammalian kidney.Current opinion in nephrology and hypertension · 2023
    Review
  5. Article
  6. Article
  7. The Epithelial Sodium Channel-An Underestimated Drug Target.International journal of molecular sciences · 2023
    Review
  8. Pendrin regulation is prioritized by anion in high-potassium diets.American journal of physiology. Renal physiology · 2023
    Article
  9. Review
  10. Kidney metabolism and acid-base control: back to the basics.Pflugers Archiv : European journal of physiology · 2022
    Review
  11. Potassium homeostasis: sensors, mediators, and targets.Pflugers Archiv : European journal of physiology · 2022
    Review
  12. KCC3a, a Strong Candidate Pathway for KFrontiers in cell and developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Truyen D PhamDepartment of Medicine, Division of Nephrology, Emory University School of Medicine, Atlanta, Georgia.
Anthony J ElengickalDepartment of Medicine, Division of Nephrology, Emory University School of Medicine, Atlanta, Georgia.
Jill W VerlanderDepartment of Medicine, University of Florida, Gainesville, Florida.
Lama Al-QusairiDepartments of Medicine, Nephrology and Physiology, Johns Hopkins School of Medicine, Baltimore, Maryland.ORCID 0000-0002-2956-2811
Chao ChenDepartment of Medicine, University of Florida, Gainesville, Florida.
Delaney C AboodDepartment of Medicine, Division of Nephrology, Emory University School of Medicine, Atlanta, Georgia.
Spencer A KingDepartment of Medicine, Division of Nephrology, Emory University School of Medicine, Atlanta, Georgia.
Johannes LoffingDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Paul A WellingDepartments of Medicine, Nephrology and Physiology, Johns Hopkins School of Medicine, Baltimore, Maryland.
Susan M WallDepartment of Medicine, Division of Nephrology, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0003-2786-8849

Funding

WNK-SPAK signaling in the Distal NephronR01DK093501 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, Paul A Welling · 2012 to 2026
$12.1M
Molecular of ROMK Channel FunctionR01DK054231 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Paul A Welling · 1998 to 2026
$7.7M
OXGR1 in Renal Intercalated Cells, Salt Transport and Diuretic EfficacyR01DK110375 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, SUSAN MARIE WALL · 2017 to 2026
$6.7M
NIDDK NIH HHS R01 DK054231NIDDK NIH HHS R01 DK093501NIDDK NIH HHS R01 DK110375
6 · The paper itself

Abstract

Pendrin is an intercalated cell Cl

Indexed as

HypokalemiaAnimalsAnion Transport ProteinsDietEpithelial Sodium ChannelsMiceMice, KnockoutAnion Transport ProteinsEpithelial Sodium Channelsepithelial Na+ channelpendrinpotassium

Identifiers

PMID35224991
PMCPMC8977139

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.