Evidence map›Paper›PMID 35224883›Full record

ArticleAndrology2022

Homocysteine levels correlate with velocimetric parameters in patients with erectile dysfunction undergoing penile duplex ultrasound.

Gianmaria Salvio, Alessandro Ciarloni, Simone Cordoni, Melissa Cutini, Nicola Delli Muti, Federica Finocchi, Francesca Firmani, Lara Giovannini, Michele Perrone, Giancarlo Balercia

Open access · hybridAbstract read
In one paragraph

Article in Andrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Article
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Gianmaria SalvioDivision of Endocrinology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ospedali Riuniti, Ancona, Italy.ORCID 0000-0001-9290-5699
Alessandro CiarloniDivision of Endocrinology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ospedali Riuniti, Ancona, Italy.
Simone CordoniDivision of Endocrinology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ospedali Riuniti, Ancona, Italy.
Melissa CutiniDivision of Endocrinology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ospedali Riuniti, Ancona, Italy.
Nicola Delli MutiDivision of Endocrinology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ospedali Riuniti, Ancona, Italy.
Federica FinocchiDivision of Endocrinology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ospedali Riuniti, Ancona, Italy.
Francesca FirmaniDivision of Endocrinology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ospedali Riuniti, Ancona, Italy.
Lara GiovanniniDivision of Endocrinology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ospedali Riuniti, Ancona, Italy.
Michele PerroneDivision of Endocrinology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ospedali Riuniti, Ancona, Italy.
Giancarlo BalerciaDivision of Endocrinology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ospedali Riuniti, Ancona, Italy.
Marche Polytechnic University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHyperhomocysteinemia may contribute to the development of endothelial dysfunction and, consequently, atherosclerosis, a systemic disease involving the vessels that may affect the cavernous arteries leading to vasculogenic erectile dysfunction. Our study aims therefore to explore the relationship between homocysteine levels and velocimetric parameters detected by basal penile duplex ultrasound such as peak systolic velocity and flaccid penile acceleration in patients with erectile dysfunction.

methodsA cross-sectional study was conducted collecting clinical, metabolic, hormonal, and instrumental (basal penile duplex ultrasound) data in patients affected by vasculogenic erectile dysfunction.

resultsData of 126 subjects affected by erectile dysfunction were collected. Mean age was 52.1 ± 12.6 years, whereas mean body mass index was 25.6 ± 4.0 kg/m

conclusionHyperhomocysteinemia is highly prevalent in erectile dysfunction patients. The results of our study show that homocysteine levels correlate with velocimetric parameters assessed by basal penile duplex ultrasound, confirming the role of hyperhomocysteinemia in the genesis of erectile dysfunction of arterial origin.

Indexed as

Erectile DysfunctionHyperhomocysteinemiaAdultCross-Sectional StudiesHomocysteineHumansMaleMiddle AgedPenile ErectionPenisHomocysteinecardiovascular diseasehomocysteinesexual dysfunction

Identifiers

PMID35224883
PMCPMC9310719
OpenAlexW4214650679

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.