Evidence map›Paper›PMID 35224837›Full record

ReviewAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2022

Nanotherapeutics in transplantation: How do we get to clinical implementation?

Leah Plumblee, Carl Atkinson, Dinesh Jaishankar, Evan Scott, Gregory T Tietjen, Satish N Nadig

Abstract readReview
In one paragraph

Review in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Targeted Expansion of Treg Cells to Induce Immune Tolerance after Kidney Transplantation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Direct application of a drug delivery platform improves heart transplantation: On the path from innovation to implementation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Nanotherapeutics in transplantation: How do we get to clinical implementation?American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Leah PlumbleeDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.ORCID 0000-0002-1990-4056
Carl AtkinsonDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.ORCID 0000-0002-0067-0210
Dinesh JaishankarDepartment of Surgery, Division of Transplant Surgery, Medical University of South Carolina, Charleston, South Carolina.ORCID 0000-0001-7906-176X
Evan ScottDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois.ORCID 0000-0002-8945-2892
Gregory T TietjenDepartment of Surgery, Department of Biomedical Engineering, Yale School of Medicine, Yale University, New Haven, Connecticut.ORCID 0000-0002-7227-2887
Satish N NadigDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0001-6090-4245

Funding

TRAINING TO IMPROVE CARDIOVASCULAR THERAPIEST32HL007260 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MENICK, DONALD R. · 1985 to 2021
$11.1M
Mechanisms and Ex Vivo Repair of Cold-Storage Injury in Human Kidney AllograftsR01DK124420 · NIDDK · YALE UNIVERSITY · PI KULKARNI, SANJAY, POBER, JORDAN S · 2020 to 2024
$2.5M
Complement driven innate and adaptive autoreactivity in lung transplantationR01HL140470 · NHLBI · UNIVERSITY OF FLORIDA · PI ATKINSON, CARL · 2018 to 2021
$2.0M
Modulating endothelial cell immunometabolism and mitochondrial morphologyimplications for organ transplantationR01AI142079 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NADIG, SATISH N · 2019 to 2023
$1.9M
Nanoparticle Therapy for Targeted Drug Delivery in Organ TransplantationK08EB019495 · NIBIB · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI NADIG, SATISH N · 2016 to 2018
$587k
NHLBI NIH HHS R01 HL140470NHLBI NIH HHS T32 HL007260NIAID NIH HHS R01 AI142079NIBIB NIH HHS K08 EB019495NIDDK NIH HHS R01 DK124420
6 · The paper itself

Abstract

Patients undergoing organ transplantation transition from one life-altering issue (organ dysfunction) to a lifelong commitment-immunosuppression. Regimens of immunosuppressive agents (ISAs) come with significant side effects and comorbidities. Recently, the use of nanoparticles (NPs) as a solution to the problems associated with the long-term and systemic use of ISAs in transplantation has emerged. This minireview describes the role of NPs in organ transplantation and discusses obstacles to clinical implementation and pathways to clinical translation.

Indexed as

Immunosuppressive AgentsOrgan TransplantationGraft RejectionHumansImmune ToleranceImmunosuppression TherapyImmunosuppressive Agentsbasic (laboratory) research/sciencebioengineeringgraft survivalimmunosuppressantimmunosuppression/immune modulationorgan perfusion and preservationorgan transplantation in generalsolid organ transplantationtranslational research/science

Identifiers

PMID35224837
PMCPMC9081154

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.