Evidence map›Paper›PMID 35224803›Full record

Observational studyJournal of magnetic resonance imaging : JMRI2022

Bias, Repeatability and Reproducibility of Liver T

Sirisha Tadimalla, Daniel J Wilson, David Shelley, Gavin Bainbridge, Margaret Saysell, Iosif A Mendichovszky, Martin J Graves, J Ashley Guthrie, John C Waterton, Geoffrey J M Parker and 1 more

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in Journal of magnetic resonance imaging : JMRI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Longitudinal relaxation rate (Magma (New York, N.Y.) · 2025
    Pooled it
  2. Accurate and precise in vivo liver 3D TMagnetic resonance in medicine · 2025
    Article
  3. Article
  4. A signal model for fat-suppressed TNMR in biomedicine · 2025
    Article
  5. Article
  6. The relaxometry hype cycle.Frontiers in physiology · 2023
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Sirisha TadimallaInstitute of Medical Physics, University of Sydney, Sydney, Australia.ORCID 0000-0003-2054-055X
Daniel J WilsonLeeds Teaching Hospitals Trust, Leeds, UK.
David ShelleyLeeds Teaching Hospitals Trust, Leeds, UK.
Gavin BainbridgeLeeds Teaching Hospitals Trust, Leeds, UK.
Margaret SaysellLeeds Teaching Hospitals Trust, Leeds, UK.
Iosif A MendichovszkyDepartment of Radiology, University of Cambridge, Cambridge, UK.
Martin J GravesDepartment of Radiology, University of Cambridge, Cambridge, UK.ORCID 0000-0003-4327-3052
J Ashley GuthrieLeeds Teaching Hospitals Trust, Leeds, UK.
John C WatertonBioxydyn Ltd, Manchester, UK.ORCID 0000-0002-7734-2290
Geoffrey J M ParkerBioxydyn Ltd, Manchester, UK.ORCID 0000-0003-2934-2234
Steven P SourbronDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Leeds Teaching Hospitals NHS Trust · GBUniversity of Cambridge · GBAbsynth Biologics (United Kingdom) · GBManchester Academic Health Science Centre · GBThe University of Sydney · AUUniversity of Sheffield · GB

Funding

Medical Research Council MR/P023398/1Medical Research Council MR/P023398/2
6 · The paper itself

Abstract

backgroundThree-dimensional variable flip angle (VFA) methods are commonly used for T PURPOSE: To measure bias, repeatability, and reproducibility of VFA T STUDY TYPE: Prospective observational. POPULATION: Eight healthy volunteers, four women, with no known liver disease. FIELD STRENGTH/SEQUENCE: 1.5-T and 3.0-T; three-dimensional steady-state spoiled gradient echo with VFAs; Look-Locker. ASSESSMENT: Traveling volunteers were scanned twice each (30 minutes to 3 months apart) on six MRI scanners from three vendors (GE Healthcare, Philips Medical Systems, and Siemens Healthineers) at two field strengths. The maximum period between the first and last scans among all volunteers was 9 months. Volunteers were instructed to abstain from alcohol intake for at least 72 hours prior to each scan and avoid high cholesterol foods on the day of the scan. STATISTICAL TESTS: Repeated measures ANOVA, Student t-test, Levene's test of variances, and 95% significance level. The percent error relative to literature liver T

resultsThe 95% confidence interval (CI) on the mean bias and mean repeatability RE of VFA T DATA

conclusionBias, repeatability, and reproducibility of VFA T LEVEL OF EVIDENCE: 1 TECHNICAL EFFICACY STAGE: 1.

Indexed as

BrainMagnetic Resonance ImagingFemaleHumansLiverMalePhantoms, ImagingProstateReproducibility of ResultsbiasliverprecisionrepeatabilityreproducibilityT1 mappingVFA

Identifiers

PMID35224803
PMCPMC9545852
OpenAlexW4214735629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.