Evidence map›Paper›PMID 35224772›Full record

ArticleJournal of leukocyte biology2022

Kakonein restores hyperglycemia-induced macrophage digestion dysfunction through regulation of cathepsin B-dependent NLRP3 inflammasome activation.

Dawei Lian, Li Zhu, Yunhong Yu, Xiaojuan Zhang, Yike Lin, Jiaying Liu, Ruifang Han, Yitong Guo, Dongpeng Cai, Wenjing Xiao and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Dawei LianDepartment of Pharmaceutical and Postdoctoral Research Station, Guangzhou University of Chinese Medicine, Guangzhou, China.
Li ZhuDepartment of Pharmaceutical and Postdoctoral Research Station, Guangzhou University of Chinese Medicine, Guangzhou, China.
Yunhong YuDepartment of Guangdong Academy of Medical Sciences and Guangdong Geriatric Institute, Guangdong Provincial People's Hospital, Guangzhou, China.
Xiaojuan ZhangDepartment of clinical pharmacology, Guangdong Provincial People's Hospital, Guangzhou, China.
Yike LinDepartment of Pharmaceutical and Postdoctoral Research Station, Guangzhou University of Chinese Medicine, Guangzhou, China.
Jiaying LiuDepartment of Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
Ruifang HanDepartment of Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
Yitong GuoDepartment of Pharmaceutical and Postdoctoral Research Station, Guangzhou University of Chinese Medicine, Guangzhou, China.
Dongpeng CaiDepartment of Pharmaceutical and Postdoctoral Research Station, Guangzhou University of Chinese Medicine, Guangzhou, China.
Wenjing XiaoDepartment of Pharmaceutical and Postdoctoral Research Station, Guangzhou University of Chinese Medicine, Guangzhou, China.
Yulin ChenDepartment of Pharmaceutical and Postdoctoral Research Station, Guangzhou University of Chinese Medicine, Guangzhou, China.
Hong HeDepartment of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Danping XuDepartment of Cardiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Chaoyang ZhengDepartment of Cardiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Xiao WangDepartment of Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
Yi HuangDepartment of Stomatology, The First Affiliated Hospital, The school of Dental Medicine, Jinan University, Guangzhou, China.
Yang ChenDepartment of Pharmaceutical and Postdoctoral Research Station, Guangzhou University of Chinese Medicine, Guangzhou, China.
Guangzhou University of Chinese Medicine · CNFirst Affiliated Hospital of Jinan University · CNGuangdong Academy of Medical Sciences · CNGuangdong Provincial People's Hospital · CNGuangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In hyperglycemia-induced complications, macrophages play important roles in disease progression, and altered digestion is a key feature that dictates macrophage function. Recent evidence indicates that kakonein (Ka) possesses anti-inflammatory activities for hyperglycemia-induced complication. In this study, we established a mouse model of Nlrp3

Indexed as

Anti-Inflammatory AgentsHyperglycemiaIsoflavonesMacrophagesPhagocytosisAnimalsCathepsin BDisease Models, AnimalInflammasomesInterleukin-1betaMiceNLR Family, Pyrin Domain-Containing 3 ProteinAnti-Inflammatory AgentsCathepsin BInflammasomesInterleukin-1betaIsoflavonesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousepuerarincathepsin Bhyperglycemiakakoneinmacrophage digestionNLRP3 inflammasome

Identifiers

PMID35224772
PMCPMC9305139
OpenAlexW4214494905

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.