Evidence map›Paper›PMID 35224662›Full record

ArticleUrolithiasis2022

How the diagnosis and the management of genetic renal phosphate leak impact the life of kidney stone formers?

Isabelle N Tostivint, Rita G Araman, Vincent Castiglione, Rana Alkouri, Rosa Vargas-Poussou, Pierre Conort, Rachida Inaoui, Marie-Paule Dousseaux, Sihem Merazga, Ziad Lalmi and 5 more

Abstract read
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In one paragraph

Article in Urolithiasis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Isabelle N TostivintDepartment of Nephrology, AP-HP, Pitie Salpetriere Hospital, 48 Boulevard de l'Hopital, 75013, Paris, France. isabelle.tostivint@aphp.fr.ORCID http://orcid.org/0000-0002-2263-9820
Rita G AramanDepartment of Nephrology, AP-HP, Pitie Salpetriere Hospital, 48 Boulevard de l'Hopital, 75013, Paris, France.
Vincent CastiglioneDepartment of Clinical Chemistry, University Hospital of Liege, Liege, Belgium.
Rana AlkouriDepartment of Metabolic Biochemistry, AP-HP, Pitie Salpetriere Hospital, Paris, France.
Rosa Vargas-PoussouDepartment of Genetics, AP-HP, European Hospital Georges Pompidou, Paris, France.
Pierre ConortDepartment of Urology, AP-HP, Pitie Salpetriere Hospital, Paris, France.
Rachida InaouiDepartment of Rheumatology, AP-HP, Pitie Salpetriere Hospital, Paris, France.
Marie-Paule DousseauxDepartment of Nutrition and Dietetics, AP-HP, Pitie Salpetriere Hospital, Paris, France.
Sihem MerazgaDepartment of Nephrology, AP-HP, Pitie Salpetriere Hospital, 48 Boulevard de l'Hopital, 75013, Paris, France.
Ziad LalmiDepartment of Nephrology, AP-HP, Pitie Salpetriere Hospital, 48 Boulevard de l'Hopital, 75013, Paris, France.
Imane ChaouiDepartment of Nephrology, AP-HP, Pitie Salpetriere Hospital, 48 Boulevard de l'Hopital, 75013, Paris, France.
Laurence PieroniDepartment of Metabolic Biochemistry, AP-HP, Pitie Salpetriere Hospital, Paris, France.
Gilbert DerayDepartment of Nephrology, AP-HP, Pitie Salpetriere Hospital, 48 Boulevard de l'Hopital, 75013, Paris, France.
Corinne Isnard-BagnisDepartment of Nephrology, AP-HP, Pitie Salpetriere Hospital, 48 Boulevard de l'Hopital, 75013, Paris, France.
Hassan IzzedineDepartment of Nephrology, Peupliers Private Hospital, Paris, France.
Sorbonne Université · FRAssistance Publique – Hôpitaux de Paris · FRRamsay Santé Hôpital privé des Peupliers · FRUniversity of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic renal phosphate leak is one of the rare disorders in recurrent stone formers with absorptive hypercalciuria. Diagnosis and appropriate management may change the life of patients. To provide answers on how and when to make the diagnosis of genetic renal phosphate leak and how medical management prevents the recurrences and changes patients' life, we conducted a retrospective study including nine patients with recurrent nephrolithiasis and a confirmed genetic mutation of a phosphate transporter between 2008 and 2019 in our multidisciplinary center at the Pitié Salpetriere Hospital, Paris, France. We compared the number and the annual rate of urological intervention before and after the diagnosis and management using the Wilcoxon test. A qualitative survey was done to evaluate the quality of life of patients. A total of 9 patients were included in this study. Patient baseline characteristics and elements supporting the diagnosis are described. We showed an effective decrease in urological intervention number (p = 0.0078) and annual rate (p = 0.0117) after the diagnosis and the appropriate management, and an improvement in the patients' quality of life. The diagnosis and the appropriate management of genetic renal phosphate leak disorder improve the quality of life by preventing stone recurrence and decreasing the number of surgical intervention.

Indexed as

Kidney CalculiPhosphatesCalciumFemaleHumansKidneyMaleQuality of LifeRetrospective StudiesCalciumPhosphatesAbsorptive hypercalciuriaGenetic diseaseKidney stonePreventionPrognosisRenal phosphate leakTreatmentTubular phosphate transporter

Identifiers

PMID35224662
OpenAlexW4214587378

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.