Evidence map›Paper›PMID 35224565›Full record

ArticleProceedings of the ... Design of Medical Devices Conference. Design of Medical Devices Conference2021

A MINIATURE LASER SPECKLE CONTRAST IMAGER FOR MONITORING OF THE NEURO-MODULATORY EFFECT OF TRANSCRANIAL FOCUSED ULTRASOUND STIMULATION.

Yinuo Zeng, Molly Acord, Tarana Parvez Kaovasia, Peng Miao, Junfeng Sun, Janaka Senarathna, Nicholas Theodore, Nitish Thakor, Amir Manbachi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the ... Design of Medical Devices Conference. Design of Medical Devices Conference, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yinuo ZengDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Molly AcordDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Tarana Parvez KaovasiaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Peng MiaoDepartment of Biomedical Engineering, Shanghai Jiaotong University, Shanghai, China.
Junfeng SunDepartment of Biomedical Engineering, Shanghai Jiaotong University, Shanghai, China.
Janaka SenarathnaDepartment of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
Nicholas TheodoreDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Nitish ThakorDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Amir ManbachiDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · US

Funding

Consequences of Cardiac Arrest: Brain InjuryR01HL071568 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GEOCADIN, ROMERGRYKO, THAKOR, NITISH VYOMESH · 2003 to 2022
$8.4M
Institutional Career Development CoreKL2TR003099 · NCATS · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2019 to 2023
$7.9M
Translational Technologies for Ameliorating Brain InjuryR01HL139158 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KANNAN, SUJATHA, THAKOR, NITISH VYOMESH · 2018 to 2021
$2.1M
NCATS NIH HHS KL2 TR003099NHLBI NIH HHS R01 HL071568NHLBI NIH HHS R01 HL139158
6 · The paper itself

Abstract

Transcranial focused ultrasound stimulation is a neuromodulation technique that is capable of exciting or suppressing the neural network. Such neuro-modulatory effects enable the treatment of brain diseases non-invasively, such as treating stroke. The neuro-modulatory effect on cerebral hemodynamics has been monitored using laser speckle contrast imaging in animal studies. However, the bulky size and stationary nature of the imaging system constrains the application of this imaging technique on research that requires the animal to have different body positions or to be awake. We present the design of a system that combines a miniature microscope for laser speckle contrast imaging and transcranial focused ultrasound stimulation, as well as, test its capability to monitor cerebral hemodynamics during stimulation and compare the result with a benchtop imaging system.

Indexed as

Cerebral Blood FlowFocused UltrasoundLaser Speckle Contrast ImagingNeuromodulation

Identifiers

PMID35224565
PMCPMC8875282
OpenAlexW3162096830

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.