ReviewFrontiers in global women's health2021
Immune System Alterations and Postpartum Mental Illness: Evidence From Basic and Clinical Research.
Review in Frontiers in global women's health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- The immune phenotype of perinatal anxiety in an anxiety-focused behavioral intervention program in Pakistan.Brain, behavior, and immunity · 2024Trial
- Genetic architecture of postpartum psychosis: from common to rare genetic variation.Molecular psychiatry · 2026Article
- Peripartum Depression as a Heart-Brain-Endocrine-Immune Syndrome: Neuroendocrine, Cardiovascular, and Inflammatory Pathways Underlying Maternal Vulnerability.Life (Basel, Switzerland) · 2026Review
- Gestational stress disrupts the neuroimmune environment in the nucleus accumbens of maternal rats.Brain, behavior, & immunity - health · 2025Article
- Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum.Molecular psychiatry · 2025Article
- Dynamics of Cytokines and Chemokines During the Peripartum Period in People Living With Human Immunodeficiency Virus.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Observational
- Hormonal contraceptives in adolescence impact the neuroimmune environment of the medial prefrontal cortex and hippocampus in female rats.Brain, behavior, and immunity · 2025Article
- Postpartum Depression: Interacting Biological Pathways and the Promising Validation of Blood-Based Biomarkers.Journal of clinical medicine · 2025Article
- Peripartum buprenorphine and oxycodone exposure impair maternal behavior and increase neuroinflammation in new mother rats.Brain, behavior, and immunity · 2025Article
- Conventional and new immunotherapies for immune system dysregulation in postpartum mood disorders: comparisons to immune system dysregulations in bipolar disorder, major depression, and postpartum autoimmune thyroid disease.Expert review of clinical immunology · 2025Review
- Impact of Stress and Anxiety on Cardiovascular Health in Pregnancy: A Scoping Review.Journal of clinical medicine · 2025Review
- Effects of postpartum hormonal changes on the immune system and their role in recovery.Acta biochimica Polonica · 2025Review
- Article
- Increased postpartum anxiety symptoms after perinatal SARS-CoV-2 infection in a large, prospective pregnancy cohort in New York City.Journal of psychiatric research · 2024Article
- Microglia depletion facilitates the display of maternal behavior and alters activation of the maternal brain network in nulliparous female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats.Neurobiology of stress · 2023Article
- Risk of postpartum readmission for depression in relation to ischaemic placental disease: a population-based study.EClinicalMedicine · 2023Article
- Sex differences in depression: An immunological perspective.Brain research bulletin · 2023Review
- Mitochondrial might: powering the peripartum for risk and resilience.Frontiers in behavioral neuroscience · 2023Review
- Assessment of the Postpartum Emotional Wellbeing among Women Participating and Not Participating in Antenatal Classes.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The postpartum period is a time associated with high rates of depression and anxiety as well as greater risk for psychosis in some women. A growing number of studies point to aberrations in immune system function as contributing to postpartum mental illness. Here we review evidence from both clinical and animal models suggesting an immune component to postpartum depression, postpartum anxiety, and postpartum psychosis. Thus far, clinical data primarily highlights changes in peripheral cytokine signaling in disease etiology, while animal models have begun to provide insight into the immune environment of the maternal brain and how central inflammation may also be contributing to postpartum mental illnesses. Further research investigating peripheral and central immune function, along with neural and endocrine interactions, will be important in successfully developing novel prevention and treatment strategies for these serious disorders that impact a large portion of new mothers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.