Evidence map›Paper›PMID 35224490›Full record

ArticleBrain communications2022

p70S6 kinase regulates oligodendrocyte differentiation and is active in remyelinating lesions.

Karelle Benardais, Isis M Ornelas, Melissa Fauveau, Tanya L Brown, Lisbet T Finseth, Radmila Panic, Cyrille Deboux, Wendy B Macklin, Teresa L Wood, Brahim Nait-Oumesmar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Regulators of Oligodendrocyte Differentiation.Cold Spring Harbor perspectives in biology · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Karelle BenardaisSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital de la Pitié-Salpêtrière, Paris, France.
Isis M OrnelasDepartment of Pharmacology, Physiology & Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ 07101, USA.
Melissa FauveauSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital de la Pitié-Salpêtrière, Paris, France.
Tanya L BrownDepartment of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Lisbet T FinsethDepartment of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Radmila PanicSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital de la Pitié-Salpêtrière, Paris, France.
Cyrille DebouxSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital de la Pitié-Salpêtrière, Paris, France.
Wendy B MacklinDepartment of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Teresa L WoodDepartment of Pharmacology, Physiology & Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ 07101, USA.
Brahim Nait-OumesmarSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital de la Pitié-Salpêtrière, Paris, France.
University of Colorado Denver · USAssistance Publique – Hôpitaux de Paris · FRRutgers, The State University of New Jersey · USCentre National de la Recherche Scientifique · FRInserm · FRPitié-Salpêtrière Hospital · FR

Funding

The role of mTOR signaling in oligodendrocyte differentiation and CNS myelinationR37NS082203 · NINDS · UNIVERSITY OF COLORADO DENVER · PI MACKLIN, WENDY B, WOOD, TERESA L · 2017 to 2023
$6.0M
The role of mTOR signaling in oligodendrocyte differentiation and CNS myelinationR01NS082203 · NINDS · UNIVERSITY OF COLORADO DENVER · PI MACKLIN, WENDY B, WOOD, TERESA L · 2012 to 2016
$3.3M
NINDS NIH HHS R01 NS082203NINDS NIH HHS R37 NS082203
6 · The paper itself

Abstract

The p70 ribosomal S6 kinases (p70 ribosomal S6 kinase 1 and p70 ribosomal S6 kinase 2) are downstream targets of the mechanistic target of rapamycin signalling pathway. p70 ribosomal S6 kinase 1 specifically has demonstrated functions in regulating cell size in

Indexed as

multiple sclerosisoligodendrocytep70S6K1pS6RP(re)-myelination

Identifiers

PMID35224490
PMCPMC8864467
OpenAlexW4211037209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.