Evidence map›Paper›PMID 35224304›Full record

ArticleBioactive materials2022

Blockading a new NSCLC immunosuppressive target by pluripotent autologous tumor vaccines magnifies sequential immunotherapy.

Hong Wu, Hongyan Li, Yiqiang Liu, Jingchen Liang, Qianshi Liu, Zhigang Xu, Zhongzhu Chen, Xia Zhang, Kun Zhang, Chuan Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

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  9. Oxidative Stress in Cardiovascular Diseases: Mechanisms and Exploring Advanced Therapies.Cardiovascular & hematological agents in medicinal chemistry · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hong WuIntegrative Cancer Center & Cancer Clinical Research Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center School of Medicine, University of Electronic Science and Technology of China, No.55, Section 4, South Ren-min Road, Chengdu, 610042, Sichuan, PR China.
Hongyan LiDepartment of Medical Ultrasound and Central Laboratory, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, No. 301 Yan-chang-zhong Road, Shanghai, 200072, PR China.
Yiqiang LiuIntegrative Cancer Center & Cancer Clinical Research Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center School of Medicine, University of Electronic Science and Technology of China, No.55, Section 4, South Ren-min Road, Chengdu, 610042, Sichuan, PR China.
Jingchen LiangIntegrative Cancer Center & Cancer Clinical Research Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center School of Medicine, University of Electronic Science and Technology of China, No.55, Section 4, South Ren-min Road, Chengdu, 610042, Sichuan, PR China.
Qianshi LiuIntegrative Cancer Center & Cancer Clinical Research Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center School of Medicine, University of Electronic Science and Technology of China, No.55, Section 4, South Ren-min Road, Chengdu, 610042, Sichuan, PR China.
Zhigang XuInternational Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, NO. 319, Red River Avenue, Yong-chuan, 402160, Chongqing, PR China.
Zhongzhu ChenInternational Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, NO. 319, Red River Avenue, Yong-chuan, 402160, Chongqing, PR China.
Xia ZhangInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), NO. 30, Gao-tan-yan-zheng Street, Chongqing, 400038, PR China.
Kun ZhangDepartment of Medical Ultrasound and Central Laboratory, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, No. 301 Yan-chang-zhong Road, Shanghai, 200072, PR China.
Chuan XuIntegrative Cancer Center & Cancer Clinical Research Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center School of Medicine, University of Electronic Science and Technology of China, No.55, Section 4, South Ren-min Road, Chengdu, 610042, Sichuan, PR China.
University of Electronic Science and Technology of China · CNChongqing University of Arts and Sciences · CNTongji University · CNArmy Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The presence of multiple immunosuppressive targets and insufficient activation and infiltration of cytotoxic T lymphocytes (CTLs) allow tumor cells to escape immune surveillance and disable anti-PD-1/PD-L1 immunotherapy. Nanobiotechnology-engineered autologous tumor vaccines (ATVs) that were camouflaged by tumor cell membrane (TCM) were designed to activate and facilitate CTLs infiltration for killing the unprotected lung tumor cells, consequently realizing the sequential immunotherapy. PDE5 was firstly screened out as a new immunosuppressive target of lung cancer in clinical practice. Immediately afterwards, phosphodiesterase-5 (PDE5) and programmed cell death 1 ligand 1 (PD-L1) dual-target co-inhibition was proposed to unfreeze the immunosuppressive microenvironment of NSCLC. Systematic studies validated that this ATVs-unlocked sequential immunotherapy after co-encapsulating PDE5 inhibitor and NO donor (

Indexed as

Autologous tumor vaccines (ATVs)Immune escape targetImmunosuppressive microenvironmentSequential immunotherapyTumor tropism

Identifiers

PMID35224304
PMCPMC8843980
OpenAlexW3209036709

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.