Evidence map›Paper›PMID 35224293›Full record

ArticleBioactive materials2022

A regeneration process-matching scaffold with appropriate dynamic mechanical properties and spatial adaptability for ligament reconstruction.

Xiaojing Xie, Junjie Xu, Jing Lin, Jia Jiang, Yunfan Huang, Jun Lu, Yuhao Kang, Yage Hu, Jiangyu Cai, Fujun Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Regenerative biomaterials · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaojing XieKey Laboratory of Textile Science & Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China.
Junjie XuDepartment of Sports Medicine, Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Jing LinKey Laboratory of Textile Science & Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China.
Jia JiangDepartment of Sports Medicine, Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Yunfan HuangKey Laboratory of Textile Science & Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China.
Jun LuKey Laboratory of Textile Science & Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China.
Yuhao KangDepartment of Sports Medicine, Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Yage HuKey Laboratory of Textile Science & Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China.
Jiangyu CaiDepartment of Sports Medicine, Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Fujun WangKey Laboratory of Textile Science & Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China.
Tonghe ZhuDepartment of Sports Medicine, Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Jinzhong ZhaoDepartment of Sports Medicine, Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Lu WangKey Laboratory of Textile Science & Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ligament regeneration is a complicated process that requires dynamic mechanical properties and allowable space to regulate collagen remodeling. Poor strength and limited space of currently available grafts hinder tissue regeneration, yielding a disappointing success rate in ligament reconstruction. Matching the scaffold retreat rate with the mechanical and spatial properties of the regeneration process remains challenging. Herein, a scaffold matching the regeneration process was designed via regulating the trajectories of fibers with different degradation rates to provide dynamic mechanical properties and spatial adaptability for collagen infiltration. This core-shell structured scaffold exhibited biomimetic fiber orientation, having tri-phasic mechanical behavior and excellent strength. Besides, by the sequential material degradation, the available space of the scaffold increased from day 6 and remained stable on day 24, consistent with the proliferation and deposition phase of the native ligament regeneration process. Furthermore, mature collagen infiltration and increased bone integration

Indexed as

Allowable spaceDynamic mechanical propertyFiberLigamentRegeneration process

Identifiers

PMID35224293
PMCPMC8844703

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.